Folate intake, alcohol consumption, cigarette smoking, and risk of colorectal adenomas

Journal of the National Cancer Institute
J A BaronE R Greenberg

Abstract

Recent evidence suggests that folic acid (and derivatives) could contribute to the protective effect of fruits and vegetables against the risk of large-bowel cancer. Other evidence indicates that alcohol drinking and cigarette smoking may impair the biologic actions of folate. We used data from an adenoma prevention trial to investigate the occurrence of colorectal adenomas (possible precursors of colorectal cancer) in association with folate intake, alcohol consumption, and cigarette smoking. Patients with at least one recent large-bowel adenoma were followed with colonoscopy 1 year and 4 years after their qualifying colon examinations. Adenomas detected after the year 1 examination were used as end points. A food-frequency questionnaire was administered at study entry and at study completion; nutrient intake at study entry was used in this analysis. All statistical tests were two-sided. After adjustment for caloric intake, dietary folate had a significant protective association with the risk of recurrence of large-bowel adenoma (P for trend = .04). However, this inverse association was attenuated by further adjustment for intake of dietary fiber and fat. Use of folate supplements was not associated with a reduction in risk. A...Continue Reading

References

Oct 21, 1992·International Journal of Cancer. Journal International Du Cancer·C J PiyathilakeC L Krumdieck
Aug 1, 1992·Japanese Journal of Cancer Research : Gann·S HonjoT Hirohata
Sep 9, 1991·International Journal of Cancer. Journal International Du Cancer·E BenitoN Muñoz
Jun 1, 1991·International Journal of Epidemiology·J L FreudenheimG Wilkinson
Jul 1, 1991·American Journal of Public Health·S H ZahmA Blair
Nov 1, 1990·Japanese Journal of Cancer Research : Gann·I KatoS Kobayashi
Jul 1, 1990·Cancer Causes & Control : CCC·M P LongneckerT C Chalmers
Sep 1, 1989·Gastroenterology·J W KikendallP Langenberg
Jul 1, 1986·American Journal of Epidemiology·W Willett, M J Stampfer
Dec 1, 1982·American Journal of Obstetrics and Gynecology·F R WitterJ R Niebyl
Feb 15, 1995·Journal of the National Cancer Institute·E GiovannucciW C Willett
Feb 15, 1995·Journal of the National Cancer Institute·M E MartínezB Levin
Jan 1, 1994·Epidemiologic Reviews·L A Peipins, R S Sandler
Jan 1, 1995·Diseases of the Colon and Rectum·G A PaspatisD G Karamanolis
Dec 1, 1994·British Journal of Cancer·M FerraroniA Decarli
Dec 15, 1994·International Journal of Cancer. Journal International Du Cancer·E F HeinemanJ B Vaught
Jul 21, 1994·The New England Journal of Medicine·E R GreenbergR W Haile
Oct 1, 1994·The American Journal of Clinical Nutrition·C J PiyathilakeC L Krumdieck
Jan 1, 1993·Epidemiologic Reviews·J D PotterS M Gapstur
May 1, 1993·Annals of Epidemiology·W C LeeC Fenoglio-Preiser
Feb 2, 1994·Journal of the National Cancer Institute·E GiovannucciW C Willett
Feb 2, 1994·Journal of the National Cancer Institute·E GiovannucciF E Speizer
Aug 15, 1993·Annals of Internal Medicine·A Anand
Jun 1, 1993·International Journal of Epidemiology·J Olsen, O Kronborg
Sep 9, 1993·International Journal of Cancer. Journal International Du Cancer·E BenitoF X Bosch
Aug 15, 1993·American Journal of Epidemiology·F Meyer, E White
May 1, 1993·Gastroenterology·R S SandlerL L Kupper
Jun 2, 1993·Journal of the National Cancer Institute·E GiovannucciW C Willett
Sep 18, 1996·Journal of the National Cancer Institute·O NyrénN Stjernberg
Dec 1, 1996·American Journal of Epidemiology·M TsengR S Sandler

❮ Previous
Next ❯

Citations

Aug 12, 2009·International Journal of Colorectal Disease·Antonia M Fernández-PeraltaJuan J González-Aguilera
Sep 27, 2005·Cancer Causes & Control : CCC·Electra D PaskettUNKNOWN Polyp Prevention Trial Study Group
May 19, 2007·Digestive Diseases and Sciences·Gregory L AustinRobert S Sandler
Sep 3, 2004·Current Treatment Options in Oncology·Christopher D Lao, Dean E Brenner
Dec 21, 2000·Current Oncology Reports·C Ritenbaugh
Aug 12, 2006·Current Treatment Options in Gastroenterology·David T Rubin, Nimisha Parekh
Nov 13, 2004·The Journal of Nutritional Biochemistry·Y I Kim
Apr 3, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·DeLeonM Ponz
Sep 4, 2007·The British Journal of Nutrition·Peter SandersonJohn A Baron
Apr 16, 2002·Journal of Internal Medicine·R M TamimiD Trichopoulos
Dec 17, 2009·Clinics in Colon and Rectal Surgery·Alyssa D Fajardo, Bruce W Robb
Jun 30, 2000·The New England Journal of Medicine·P A Jänne, R J Mayer
Jun 1, 2004·Nutrition Research Reviews·J E CadeB M Margetts
Dec 25, 2003·The Proceedings of the Nutrition Society·John J Reilly, Zoe C McDowell
Feb 3, 2000·Journal of the National Cancer Institute·T E RohanA B Miller
May 22, 2003·Journal of the National Cancer Institute·John A BaronE Robert Greenberg
Aug 10, 2007·Journal of the National Cancer Institute·Eunyoung ChoEdward L Giovannucci
Jul 19, 2003·Revue médicale de Liège·M PolusG Fillet
Mar 27, 2004·Southern Medical Journal·Claudia HopenhaynGilbert A Boissonneault
Aug 29, 2012·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Takashi UchiyamaAtsushi Nakajima
Jan 14, 2012·BMJ Open·Tale Norbye WienMarianne Klemp
Nov 21, 1998·Gut·M Langman, P Boyle
Oct 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jane C FigueiredoJohn A Baron
Jul 1, 2008·Therapeutic Advances in Gastroenterology·Julian A Abrams
Dec 7, 2013·BMC Surgery·Francesca NolfoAntonio Biondi
Aug 6, 2008·World Journal of Gastroenterology : WJG·Richard JaszewskiAdhip P N Majumdar
Nov 20, 2009·The American Journal of Clinical Nutrition·Aditi HazraJohn A Baron
Mar 26, 2011·Cancer Causes & Control : CCC·Loïc Le MarchandRobert Decker
May 10, 2003·Journal of Women's Health·Edward Giovannucci
Apr 30, 2013·International Journal of Hygiene and Environmental Health·Tian-Cheng WangGuang Jia
Dec 17, 2015·The British Journal of Surgery·H-C PommergaardH Raskov
Nov 30, 2011·Best Practice & Research. Clinical Gastroenterology·Xiangwei WuErnest Hawk
Oct 23, 2014·Journal of Cancer Prevention·Yeong Mi ParkJung Eun Lee
Jan 2, 2008·Gastroenterology·Unhee LimRachael Stolzenberg-Solomon
Nov 21, 2007·Gastroenterology·Richard F A LoganUNKNOWN ukCAP Trial Group
Apr 9, 2008·Gastroenterology·Nadir Arber, Bernard Levin

❮ Previous
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