PMID: 6982057Sep 1, 1982Paper

Folate metabolism in man: the effect of malignant disease

British Journal of Cancer
A M SalehJ Walters

Abstract

The metabolism of [2-14C]+[3', 5', 7, 9-3H] folic acid and [214C]+[3', 5', 7, 9-3H] 10-formylfolate was studied in hospital inpatients. Metabolites detected in the urine after folic acid feeding included the unchanged compound, other folates and a number of breakdown products, such as p-acetamidobenzoyl-L-glutamate and p-acetamidobenzoate. This confirms the existence of a folate catabolic pathway in man. Patients with malignant disease excreted less of the dose in urine, incorporated more into the reduced folate pool, and showed decreased catabolism of folate, when compared to controls. 10-Formylfolate was excreted largely unchanged, and appears not to be reduced by man. Also 10-formylfolate interfered with the reduction of folic acid given simultaneously.

Citations

Aug 24, 2004·The American Journal of Clinical Nutrition·Yumei LinAndrew J Clifford
May 2, 1986·Klinische Wochenschrift·H LinkP Ostendorf
Jul 8, 1999·The Journal of Nutrition·J E Baggott, G L Johanning
Jan 1, 1987·Cancer Metastasis Reviews·S Holmes, J W Dickerson
Nov 1, 1983·Biochemical Pharmacology·A E GuestJ A Blair
Dec 1, 1984·Cancer Letters·W ChmurzyńskaB Grzelakowska-Sztabert

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