Folate Receptor β (FRβ) Expression in Tissue-Resident and Tumor-Associated Macrophages Associates with and Depends on the Expression of PU.1.

Cells
Rafael SamaniegoAmaya Puig-Kröger

Abstract

As macrophages exhibit a huge functional plasticity under homeostasis and pathological conditions, they have become a therapeutic target for chronic inflammatory diseases. Hence, the identification of macrophage subset-specific markers is a requisite for the development of macrophage-directed therapeutic interventions. In this regard, the macrophage-specific Folate Receptor β (FRβ, encoded by the FOLR2 gene) has been already validated as a target for molecular delivery in cancer as well as in macrophage-targeting therapeutic strategies for chronic inflammatory pathologies. We now show that the transcriptome of human macrophages from healthy and inflamed tissues (tumor; rheumatoid arthritis, RA) share a significant over-representation of the "anti-inflammatory gene set", which defines the gene profile of M-CSF-dependent IL-10-producing human macrophages (M-MØ). More specifically, FOLR2 expression has been found to strongly correlate with the expression of M-MØ-specific genes in tissue-resident macrophages, tumor-associated macrophages (TAM) and macrophages from inflamed synovium, and also correlates with the presence of the PU.1 transcription factor. In fact, PU.1-binding elements are found upstream of the first exon of FOLR2 an...Continue Reading

References

Feb 4, 2003·Nature Reviews. Cancer·Daniel G Tenen
Apr 2, 2004·Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan·Makoto NaitoTakashi Yamamoto
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Frank A W VerreckTom H M Ottenhoff
Apr 20, 2004·Advanced Drug Delivery Reviews·Hala Elnakat, Manohar Ratnam
May 17, 2005·Nature Immunology·Zhengfan JiangBruce Beutler
Aug 10, 2006·Plant Physiology·Aleel K Grennan
Sep 6, 2007·The Journal of Clinical Investigation·Lisa C ZabaMichelle A Lowes
Jan 29, 2008·Gynecologic Oncology·Kimberly R KalliLynn C Hartmann
Jun 14, 2008·Nature Reviews. Immunology·John A Hamilton
Jan 15, 2009·Nature Reviews. Cancer·Alain EychèneCelio Pouponnot
May 2, 2009·Journal of Leukocyte Biology·Andrew J FleetwoodJohn A Hamilton
Dec 9, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Minggang ZhangXuetao Cao
Nov 15, 2011·Cell·Ivan ZanoniJonathan C Kagan
Feb 22, 2012·Annals of Surgical Oncology·Hiroshi KuraharaShoji Natsugoe
May 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Derek C LaceyJohn A Hamilton
Jan 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mateo de las Casas-EngelAngel L Corbí
Apr 17, 2013·BMC Bioinformatics·Edward Y ChenAvi Ma'ayan
Apr 27, 2013·Nature·Thomas A WynnJeffrey W Pollard
Sep 24, 2013·Nature Medicine·Stephanie M PyonteckJohanna A Joyce
Apr 18, 2014·Nature·Enrica BianchiGavin J Wright
Sep 17, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zbigniew ZasłonaMarc Peters-Golden
Oct 17, 2014·The Journal of Pathology·Blanca Soler PalaciosAmaya Puig-Kröger
Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kory J LavineDouglas L Mann
Mar 24, 2015·The Journal of Clinical Investigation·Jun XuHidekazu Tsukamoto

❮ Previous
Next ❯

Citations

Mar 7, 2021·Cells·Yasmina Juarranz

❮ Previous
Next ❯

Methods Mentioned

BETA
FCS
transfection
Xenograft
Chips
ChIP-Seq

Software Mentioned

ENRICHR
cBioPortal
Genevestigator®
Cistrome data browser
Roche software
TIMER
WashU Epigenome Browser
Leica Confocal

Related Concepts

Related Feeds

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.