Folate-receptor-targeted laser-activable poly(lactide-co -glycolic acid) nanoparticles loaded with paclitaxel/indocyanine green for photoacoustic/ultrasound imaging and chemo/photothermal therapy

International Journal of Nanomedicine
Feng-Qiu LiuHai-Tao Ran

Abstract

Cancer is one of the most serious threats to human health. Precision medicine is an innovative approach to treatment, as part of which theranostic nanomedicine has been studied extensively. However, the required biocompatibility and substantial cost for the approval of nanomedicines hinder their clinical translation. We designed a novel type of theranostic nanoparticle (NP) folate-receptor-targeted laser-activatable poly(lactide-co-glycolic acid) (PLGA) NPs loaded with paclitaxel (Ptx)/indo-cyanine green (ICG)-folic acid-polyethylene glycol (PEG)-PLGA-Ptx@ICG-perfluorohexane (Pfh)- using safe and approved materials and drugs, which would facilitate clinical translation. With laser irradiation, highly efficient photothermal therapy can be achieved. Additionally, targeted NPs can be activated by near-infrared laser irradiation at a specific region, which leads to the sharp release of Ptx at areas of high folate-receptor expression and ensures a higher Ptx concentration within the tumor region, thereby leading to chemo/photothermal synergistic antitumor efficacy. Meanwhile, the NPs can be used as a dual-modality contrast agent for photoacoustic and ultrasound imaging. FA-PEG-PLGA-Ptx@ICG-Pfh NPs were prepared by sonification metho...Continue Reading

Citations

Mar 25, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lei FanYuxin Wang
Aug 21, 2019·Anti-cancer Agents in Medicinal Chemistry·Paromita KunduSanjeeb K Sahoo
Jun 12, 2019·Contrast Media & Molecular Imaging·Sara GargiuloMarcello Mancini
Jan 27, 2019·International Journal of Molecular Sciences·Shriya S SrinivasanClemens Burda
Feb 5, 2021·ACS Biomaterials Science & Engineering·Pei-Yao XuAi-Zheng Chen
Apr 3, 2021·Advanced Drug Delivery Reviews·Paz Boix-MontesinosMaría J Vicent
Aug 11, 2021·Polymers·Maritza Fernández, Jahir Orozco
Mar 11, 2019·ACS Biomaterials Science & Engineering·Joel F LuskBarbara S Smith
Aug 6, 2021·Current Pharmaceutical Design·Poonam ParasharShubhini A Saraf

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Methods Mentioned

BETA
dynamic light scattering
scanning electron microscopy
fluorescence imaging
nuclear magnetic resonance
fluorescence-imaging

Software Mentioned

SPSS

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