Folate receptor-targeted multimodal polymersomes for delivery of quantum dots and doxorubicin to breast adenocarcinoma: In vitro and in vivo evaluation

International Journal of Pharmaceutics
Mona AlibolandiFarzin Hadizadeh

Abstract

In this study, we report the design and delivery of tumor-targeted, quantum dot (QD) and doxorubicin (DOX)-encapsulated PEG-PLGA nanopolymersomes (NPs) for the imaging and chemotherapy of breast cancer. To achieve active cancer targeting, QD and DOX-encapsulated NPs were conjugated with folate for folate-binding protein receptor-guided delivery, which overexpressed in many cancer cells. Hydrophobic DOX and hydrophilic MSA-capped QD were encapsulated in the bilayer and core of the PEG-PLGA nanopolymersomes, respectively. The data show that the formulated NPs sustained DOX release for a period of 12 days. Fluorescence microscopy and MTT assay demonstrated that the developed folate-targeted DOX-QD NPs had higher cytotoxicity than non-targeted NPs and the free form of the drug; moreover, they preferentially accumulated in 4T1 and MCF-7 cells in vitro. In vivo experiments including whole organ tissue-homogenate analysis and organ fluorescence microscopy imaging of BALB/c mice bearing 4T1 breast adenocarcinoma showed that the folate receptor-targeted QD encapsulated NPs accumulate at tumor sites 6h following intravenous injection. Acute toxicity studies of the prepared targeted QD-loaded NPs showed no evidence of long-term harmful hi...Continue Reading

References

May 15, 1999·Science·B M DischerD A Hammer
Oct 16, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·B JeongS W Kim
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MaedaK Hori
Aug 10, 2002·Science·Dennis E Discher, Adi Eisenberg
Apr 6, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fariyal Ahmed, Dennis E Discher
Dec 14, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fenghua MengJan Feijen
Feb 19, 2005·Seminars in Oncology·David S AlbertsAlberto A Gabizon
Aug 18, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jennifer L PelleyMarc A Saner
Aug 29, 2009·Analytical and Bioanalytical Chemistry·Manuela F Frasco, Nikos Chaniotakis
Dec 8, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ranjita Misra, Sanjeeb K Sahoo
Mar 17, 2010·Macromolecular Bioscience·Kamal K UpadhyaySébastien Lecommandoux
Jun 29, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jay Prakash Jain, Neeraj Kumar
Jun 15, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·You Han Bae, Kinam Park
May 24, 2012·International Journal of Nanomedicine·Chih-Jen WenJia-You Fang
Jul 11, 2012·Accounts of Chemical Research·Françoise M Winnik, Dusica Maysinger
Nov 24, 2012·Chemical Society Reviews·Ken-Tye YongParas N Prasad
Apr 9, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wen-Hsuan ChiangHsin-Cheng Chiu
May 23, 2013·Macromolecular Bioscience·Marjoke F DebetsJan C M van Hest
Aug 24, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Jing XuLiyan Qiu
Nov 12, 2013·Biomaterials·Lanxia ZhaoYuxia Luan
Jun 11, 2014·ACS Applied Materials & Interfaces·Mei-Hsiu LaiHyunjoon Kong
Oct 9, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chelsea BolyardBalveen Kaur
Dec 4, 2014·Breast Cancer Research : BCR·Anthony HowellMichelle N Harvie
Jan 23, 2015·International Journal of Nanomedicine·Guimiao LinKen-Tye Yong
Apr 29, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mona AlibolandiFarzin Hadizadeh
May 6, 2015·PloS One·Andrew D WongPeter C Searson
Jun 5, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Di WuXiabin Jing
Jul 3, 2015·Biomolecular Concepts·Ugir Hossain Sk, Chie Kojima
Jul 6, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Behdokht BahramiMohammad Hojjat-Farsangi
Jul 15, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mona AlibolandiFarzin Hadizadeh
Aug 28, 2015·Journal of Biomedical Nanotechnology·Yongjun LiuNa Zhang

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Citations

Oct 19, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mona AlibolandiMohammad Ramezani
Jan 25, 2017·International Journal of Pharmaceutics·Marzieh MohammadiMona Alibolandi
Mar 17, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ajmeeta SangtaniJames B Delehanty
Feb 16, 2018·Advanced Materials·Eugenia PuglieseDimitrios I Zeugolis
Oct 3, 2017·Nanomedicine·Ashwin NarainYogita Patil-Sen
Feb 18, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Cristina NúñezMaría Del Pilar Chantada
Dec 7, 2018·Biomaterials Science·Mingming ZhangChun Wang
Oct 12, 2019·Current Pharmaceutical Design·Kandasamy SaravanakumarMyeong-Hyeon Wang
Dec 12, 2018·Journal of Nanobiotechnology·Gitanjali AsampilleHanudatta S Atreya
Jun 7, 2020·Drug Delivery and Translational Research·Abhishek Kumar SharmaDeepak N Kapoor
Nov 20, 2018·Frontiers in Pharmacology·Sima RezvantalabFabian Kiessling
Oct 28, 2020·Biomaterials Science·Yanan LiYouqing Shen
Jul 12, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mahsa ShahriariMona Alibolandi
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Amin AmaniMahdi Nohtani
Nov 22, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mara GonçalvesHelena Tomás
Feb 4, 2021·Biomedicines·Sulltana JahanEzharul Hoque Chowdhury
Dec 29, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fatemeh ArasteMona Alibolandi
Feb 22, 2021·Biomaterials·Yingbin SuYouqing Shen
Jun 24, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Viet Hoang ManPhuong H Nguyen
Aug 10, 2021·Progress in Biomaterials·Hamed Mohammad GholihaNajmeh Alizadeh

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