PMID: 8608361Dec 1, 1995Paper

Folate supplementation and methotrexate

British Journal of Rheumatology
B A Dijkmans

Abstract

This review concentrates on the influence of folate supplementation on the toxicity and efficacy of methotrexate (MTX) in rheumatoid arthritis patients. The design, type of folate supplementation and timing of supplementation vary considerably between the six published controlled studies. Folate supplementation seems to have no effect on the efficacy of MTX but may influence toxicity in a favourable way. Further studies are needed to assess the type of supplementation (folic acid, folinic acid), the predisposing factors for toxicity and cost effectiveness.

Citations

Oct 1, 1996·Clinical Biochemistry·S J Soldin
Oct 6, 1997·Clinics in Dermatology·S SaidG D Weinstein
Oct 21, 2006·Lancet Neurology·Edward Reynolds
Jul 10, 1998·The Proceedings of the Nutrition Society·R H Martin
Oct 14, 2004·Annals of the Rheumatic Diseases·B N Cronstein
Feb 26, 2008·Leukemia & Lymphoma·Alan Kambiz Fotoohi, Freidoun Albertioni
Nov 15, 1997·Rheumatic Diseases Clinics of North America·J L Hillson, D E Furst
Apr 7, 2012·Molecular and Cellular Endocrinology·Caroline Candida DeOliveiraAlessandra Gambero
May 8, 1998·Seminars in Arthritis and Rheumatism·A E van EdeL B van de Putte
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Joseph Boullata
Dec 31, 2009·The Annals of Pharmacotherapy·Alexander L RogovikRan D Goldman
May 8, 2003·Nutrition and Cancer·Thomas A SellersJohn D Potter
May 26, 2005·Pharmacological Reviews·Bruce N Cronstein
Jun 4, 2013·The Cochrane Database of Systematic Reviews·Beverley SheaPeter Tugwell
Mar 29, 2003·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·K L RennieS A Jebb

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