Folate supplementation in people with sickle cell disease

The Cochrane Database of Systematic Reviews
Ruchita DixitPatrick J Stover

Abstract

Sickle cell disease is a group of disorders that affects haemoglobin, which causes distorted sickle- or crescent-shaped red blood cells. It is characterized by anaemia, increased susceptibility to infections and episodes of pain. The disease is acquired by inheriting abnormal genes from both parents, the combination giving rise to different forms of the disease. Due to increased erythropoiesis in people with sickle cell disease, it is hypothesized that they are at an increased risk for folate deficiency. For this reason, children and adults with sickle cell disease, particularly those with sickle cell anaemia, commonly take 1 mg of folic acid orally every day on the premise that this will replace depleted folate stores and reduce the symptoms of anaemia. It is thus important to evaluate the role of folate supplementation in treating sickle cell disease. To analyse the efficacy and possible adverse effects of folate supplementation (folate occurring naturally in foods, provided as fortified foods or additional supplements such as tablets) in people with sickle cell disease. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Haemoglobinopathies Trials Register comprising references identified from comprehensiv...Continue Reading

References

Mar 1, 1975·Scandinavian Journal of Haematology·Y K Liu
Aug 1, 1983·British Journal of Haematology·L M RabbG R Serjeant
Feb 2, 1995·The New England Journal of Medicine·J SelhubI H Rosenberg
Sep 18, 1997·Lancet·G R Serjeant
Jun 14, 2003·The Cochrane Database of Systematic Reviews·M J TaylorG Goodwin
Nov 25, 1949·Science·L PAULING, H A ITANO
Oct 12, 2004·Lancet·Marie J Stuart, Ronald L Nagel
Dec 8, 2005·The American Journal of Clinical Nutrition·David J StottRudi G J Westendorp
May 6, 2009·Annals of Internal Medicine·Tracy WolffUNKNOWN U.S. Preventive Services Task Force
Apr 2, 2010·International Journal of Epidemiology·Hannah BlencoweJoy Lawn
Apr 24, 2010·Stroke; a Journal of Cerebral Circulation·Meng LeeJeffrey L Saver
Dec 7, 2010·Lancet·David C ReesMark T Gladwin
May 20, 2011·The American Journal of Clinical Nutrition·Elizabeth A YetleyMary Frances Picciano
Dec 7, 2011·American Journal of Preventive Medicine·Scott D GrosseThomas N Williams
Oct 12, 2013·International Health·N GaladanciA D Adekile
Oct 8, 2014·Blood·Trisha E WongRichard Lottenberg
Mar 17, 2015·JAMA : the Journal of the American Medical Association·Yong HuoUNKNOWN CSPPT Investigators

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Citations

Jul 8, 2017·Critical Reviews in Food Science and Nutrition·Agartha Ohemeng, Isaac Boadu
May 12, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Clóvis PanizElvira Maria Guerra-Shinohara
Oct 1, 2020·Cerebral Cortex·Angelo Harlan De CrescenzoKonstantinos S Zarbalis

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