Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis.

Arthritis Research & Therapy
Chrystal M PaulosPhilip S Low

Abstract

Activated macrophages express a cell surface receptor for the vitamin folic acid. Because this receptor is inaccessible or not measurably expressed on other normal cells, folic acid has been recently exploited to selectively deliver attached radio-emitters to sites of activated macrophage accumulation, allowing scintigraphic imaging of inflamed joints and organs of arthritic rats. We demonstrate here that folate-linked haptens can also be targeted to activated macrophages, decorating their cell surfaces with highly immunogenic molecules. Under conditions in which the rodent has already been immunized against keyhole limpet hemocyanine-(fluorescein isothiocyanate) FITC, activated macrophages are eliminated. Administration of folate-FITC conjugates to rodents with experimental arthritis attenuates (a) systemic and peri-articular inflammation, (b) bone and cartilage degradation, and (c) arthritis-related body weight loss. Treatment with folate-hapten conjugates is comparable to methotrexate, etanercept, anakinra, and celecoxib at alleviating the symptoms of arthritis. We conclude that reduction of activated macrophages by folate-targeted immunotherapy can ameliorate the symptoms of arthritis in two rodent models of the disease.

References

Jan 1, 1994·Annals of the Rheumatic Diseases·G YanniB Bresnihan
Mar 1, 1993·The Journal of Clinical Investigation·G HahnG R Burmester
Jan 1, 1996·Arthritis and Rheumatism·D MulherinB Bresnihan
Nov 30, 2000·Arthritis Research·R W KinneG R Burmester
May 15, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·L A DipietroR L Gamelli
Jul 5, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·C Richard-Miceli, M Dougados
Apr 10, 2002·Cancer Immunology, Immunotherapy : CII·Yingjuan Lu, Philip S Low
Jul 19, 2002·Arthritis and Rheumatism·Mary Jo TurkPhilip S Low
Oct 9, 2002·Cellular Microbiology·Manuela PulitiLuciana Tissi
Oct 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Shinichi KatoKoji Takeuchi
May 31, 2003·Nature Reviews. Drug Discovery·Josef S Smolen, Günter Steiner
Nov 20, 2003·The Journal of Laboratory and Clinical Medicine·Tamaki YamadaMakoto Itoh
Apr 6, 2004·Rheumatic Diseases Clinics of North America·Hongtao Liu, Richard M Pope
Apr 23, 2004·American Journal of Physiology. Cell Physiology·Ruben M SandovalBruce A Molitoris
May 19, 2004·American Journal of Surgery·Julie E Park, Adrian Barbul
Dec 16, 2004·Herz·David HürlimannFrank Ruschitzka
Feb 5, 2005·Nature Reviews. Drug Discovery·Simon Frantz
Mar 4, 2005·Arthritis Research & Therapy·Wei-Tsung ChenChing-Hsuan Tung
Jan 8, 2008·Arthritis Research & Therapy·Raimund W KinneGerd-R Burmester
Jun 18, 2010·Cardiovascular Therapeutics·Louise E Full, Claudia Monaco

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Citations

Feb 25, 2011·Arthritis Research & Therapy·Luke L Gompels, Ewa M Paleolog
Dec 24, 2011·Molecular Medicine·Yi-Cheng Wang, En-Pei Isabel Chiang
Aug 30, 2008·Expert Opinion on Drug Delivery·Ingo H Tarner, Ulf Müller-Ladner
Mar 6, 2008·Expert Opinion on Drug Delivery·Xiaobin ZhaoRobert J Lee
Aug 29, 2014·Molecular Pharmaceutics·Bindu VarghesePhilip S Low
Dec 6, 2011·Archives of Pharmacal Research·Samir Mitragotri, Jin-Wook Yoo
Jun 25, 2019·Cardiovascular Research·Mark G MacAskillAdriana A S Tavares
May 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liyun WangLi Qiu
May 28, 2011·Arthritis and Rheumatism·Thommey P ThomasJames R Baker
Aug 6, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Lindsay E KelderhousePhilip S Low
Jul 8, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Michael J HansenPhilip S Low
May 9, 2021·Bioorganic & Medicinal Chemistry Letters·Chelvam VenkateshPhilip S Low
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wilfredo Ayala-LópezPhilip S Low
Jun 14, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Balasubramanian VaitilingamPhilip S Low
Jan 23, 2014·Molecular Pharmaceutics·N Achini BandaraPhilip S Low

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