Folate treatment of pregnant rat dams abolishes metabolic effects in female offspring induced by a paternal pre-conception unhealthy diet

Diabetologia
Jian LiBerthold Hocher

Abstract

Paternal high-fat diet prior to mating programmes impaired glucose tolerance in female offspring. We examined whether the metabolic consequences in offspring could be abolished by folate treatment of either the male rats before mating or the corresponding female rats during pregnancy. Male F0 rats were fed either control diet or high-fat, high-sucrose and high-salt diet (HFSSD), with or without folate, before mating. Male rats were mated with control-diet-fed dams. After mating, the F0 dams were fed control diet with or without folate during pregnancy. Male, but not female offspring of HFSSD-fed founders were heavier than those of control-diet-fed counterparts (p < 0.05 and p = 0.066 in males and females, respectively). Both male and female offspring of HFSSD-fed founders were longer compared with control (p < 0.01 for both sexes). Folate treatment of the pregnant dams abolished the effect of the paternal diet on the offspring's body length (p ˂ 0.05). Female offspring of HFSSD-fed founders developed impaired glucose tolerance, which was restored by folate treatment of the dams during pregnancy. The beta cell density per pancreatic islet was decreased in offspring of HFSSD-fed rats (-20% in male and -15% in female F1 offspring,...Continue Reading

References

Apr 10, 1993·Lancet·D J BarkerJ S Robinson
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Eero KajantieSture Andersson
May 6, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C Thone-ReinekeB Hocher
Oct 22, 2010·Nature·Michael K Skinner
Nov 30, 2011·Epigenomics·Boris Novakovic, Richard Saffery
Jul 23, 2013·Biochimica Et Biophysica Acta·Lyda WilliamsMaureen J Charron
Jan 15, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sheau-Fang NgMargaret J Morris
Feb 13, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Dirk S PaulStephan Beck
Apr 15, 2014·Nature Neuroscience·Katharina GappIsabelle M Mansuy
Oct 11, 2014·Annals of Nutrition & Metabolism·Nicole O McPhersonMichelle Lane
Oct 11, 2014·Kidney & Blood Pressure Research·Christoph ReichetzederBerthold Hocher
Feb 19, 2015·American Journal of Physiology. Endocrinology and Metabolism·Nicole O McPhersonMichelle Lane
Aug 8, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Minoru TerashimaKathrin Muegge
Feb 11, 2016·Nature Communications·Bonnie R JoubertStephanie J London
Mar 5, 2016·Nucleic Acids Research·Cecilia LövkvistJan O Haerter
May 14, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Berthold HocherElke Schaeffeler
Jun 25, 2016·The Journal of Endocrinology·Menghong Yan, Qiwei Zhai
Jul 28, 2016·Journal of Hypertension·Jian LiBerthold Hocher
Aug 12, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Christoph ReichetzederBerthold Hocher
Oct 13, 2016·Frontiers in Physiology·Anastasia AsimakopoulouRalf Weiskirchen
Jan 5, 2017·Scientific Reports·Mohamed A AbdelmegeedByoung-Joon Song
Mar 7, 2017·Nature Reviews. Nephrology·Berthold Hocher, Jerzy Adamski
Sep 2, 2017·BMC Musculoskeletal Disorders·Xinxin WangXiang Gao
Sep 9, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Emma L BeckettMark Lucock

❮ Previous
Next ❯

Citations

Mar 13, 2019·American Journal of Physiology. Endocrinology and Metabolism·Michael D ThompsonNicholas Oliver Davidson
May 28, 2019·Current Diabetes Reports·Lei Su, Mary Elizabeth Patti
Oct 8, 2020·Hepatology Communications·Michael D Thompson
Nov 29, 2020·BMC Biology·Joanna RutkowskaShinichi Nakagawa
Jul 13, 2019·Physiology & Behavior·Nicole YadonKimberly R Shorter
Aug 30, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rui ZhaoLihong Liu
May 31, 2021·European Journal of Nutrition·Roya Kolahdouz-MohammadiAmin Salehi-Abargouei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.