Folates in bread: retention during bread-making and in vitro bioaccessibility.

European Journal of Nutrition
Veronica E OhrvikCornelia M Witthöft

Abstract

Bread is an important folate source in several countries. However, bread-making was reported to cause losses of endogenous bread folates (approximately 40%) as well as added synthetic folic acid (approximately 30%). Furthermore, the bread matrix is suggested to inhibit absorption of folates. To (1) estimate retention of both, endogenous folates and synthetic fortificants, during bread-making, (2) assess in vitro folate bioaccessibility from breads and a breakfast meal and (3) assess in vitro folate uptake. Retention of folate forms was assessed by preparing fortified (folic acid and [6S]-5-CH(3)-H(4)folate) wholemeal breads and collect samples from dough, proofed dough and the bread. In vitro folate bioaccessibility was assessed using the TNO gastrointestinal model TIM. In vitro folate uptake was assessed using a novel Caco-2 cell/stable isotope model. Folate content in samples was measured using LCMS. Bread-making resulted in losses of 41% for endogenous folates and up to 25 and 65% for folic acid and [6S]-5-CH(3)-H(4)folate fortificant, respectively. 75% of endogenous bread folates and 94% of breakfast folates were bioaccessible as assessed by TIM. From [6S]-5-CH(3)-H(4)folate-fortified bread, relative folate uptake into Caco...Continue Reading

References

Dec 24, 1992·The New England Journal of Medicine·A E Czeizel, I Dudás
May 24, 1990·Biochimica Et Biophysica Acta·J B MasonI H Rosenberg
Aug 26, 1998·Toxicology and Applied Pharmacology·J Tallkvist, H Tjälve
Mar 29, 2001·The American Journal of Clinical Nutrition·E J KoningsP A van den Brandt
Apr 30, 2003·The American Journal of Clinical Nutrition·Floor V A van OortPetra Verhoef
Aug 9, 2003·Journal of Agricultural and Food Chemistry·Susan SalovaaraAnn-Sofie Sandberg
Jul 19, 2005·Plant Foods for Human Nutrition·Elzbieta Gujska, Katarzyna Majewska
Jul 10, 2007·The American Journal of Clinical Nutrition·Balasubramaniem AshokkumarHamid M Said
Aug 23, 2007·European Journal of Nutrition·Clara LemosConceição Calhau
Mar 11, 2008·The American Journal of Clinical Nutrition·A David SmithHelga Refsum
Feb 5, 2009·The American Journal of Clinical Nutrition·Veronica E OhrvikCornelia M Witthöft

❮ Previous
Next ❯

Citations

Mar 19, 2016·Food Chemistry·Minnamari EdelmannVieno Piironen
Sep 7, 2016·International Journal of Food Sciences and Nutrition·Carlos Mário Martins SilveiraHelena Maria Pinheiro-Sant'ana
Jan 10, 2017·Current Opinion in Biotechnology·Joana Díaz-GómezPaul Christou
Aug 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thomas Bachmann, Michael Rychlik
Feb 24, 2021·Food Chemistry·Fengyuan LiuVieno Piironen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.