Fold-change detection and scale invariance of cell-cell signaling in social amoeba

Proceedings of the National Academy of Sciences of the United States of America
Keita KaminoSatoshi Sawai

Abstract

Cell-cell signaling is subject to variability in the extracellular volume, cell number, and dilution that potentially increase uncertainty in the absolute concentrations of the extracellular signaling molecules. To direct cell aggregation, the social amoebae Dictyostelium discoideum collectively give rise to oscillations and waves of cyclic adenosine 3',5'-monophosphate (cAMP) under a wide range of cell density. To date, the systems-level mechanism underlying the robustness is unclear. By using quantitative live-cell imaging, here we show that the magnitude of the cAMP relay response of individual cells is determined by fold change in the extracellular cAMP concentrations. The range of cell density and exogenous cAMP concentrations that support oscillations at the population level agrees well with conditions that support a large fold-change-dependent response at the single-cell level. Mathematical analysis suggests that invariance of the oscillations to density transformation is a natural outcome of combining secrete-and-sense systems with a fold-change detection mechanism.

References

Feb 26, 1976·Nature·J Aldridge, E K Pye
Dec 1, 1974·Journal of General Microbiology·F Alcantara, M Monk
Jul 16, 1982·Science·D E KoshlandJ B Stock
Jun 1, 1994·Molecular Biology of the Cell·R H InsallP N Devreotes
Mar 1, 1994·Mathematical Biosciences·Y Tang, H G Othmer
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·E Pálsson, E C Cox
Jul 11, 1997·Science·B Wang, A Kuspa
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·J LauzeralA Goldbeter
Feb 12, 1996·Physical Review Letters·K J LeeR E Goldstein
Jun 14, 2002·Cell·Miho Iijima, Peter Devreotes
Nov 5, 2003·Molecular Biology of the Cell·Marten PostmaPeter J M Van Haastert
Jul 3, 2004·The Journal of Biological Chemistry·Viacheslav O NikolaevMartin J Lohse
Nov 10, 2004·The Journal of Cell Biology·Atsuo T SasakiRichard A Firtel
Jul 29, 2008·Ageing Research Reviews·Vanessa C McMainsAlan R Kimmel
Aug 30, 2008·Journal of Microscopy·G L Garcia, C A Parent
Oct 25, 2008·Current Biology : CB·Sheng ZhangRichard A Firtel
Dec 17, 2009·Molecular Cell·Lea Goentoro, Marc W Kirschner
Apr 16, 2010·Development·Kana IshimatsuHiroyuki Takeda
Apr 24, 2010·Science·Thomas GregorSatoshi Sawai
Aug 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Oren ShovalUri Alon
Mar 10, 2011·Science·O WartlickM González-Gaitán
Mar 18, 2011·Nature Protocols·Sebastian BörnerViacheslav O Nikolaev
May 19, 2011·Development, Growth & Differentiation·Keita KaminoSatoshi Sawai
Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Milena D LazovaThomas S Shimizu
Nov 8, 2012·PLoS Computational Biology·Maja Skataric, Eduardo D Sontag
Jan 8, 2013·Journal of the Royal Society, Interface·Abdullah HamadehEduardo Sontag
Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Daisuke TaniguchiSatoshi Sawai
Jul 5, 2013·PLoS Computational Biology·Koichi Fujimoto, Satoshi Sawai
Aug 2, 2013·Journal of Cell Science·Joseph A BrzostowskiAlan R Kimmel

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Citations

Mar 6, 2018·PLoS Computational Biology·Rui Zhen Tan, Keng-Hwee Chiam
Jun 9, 2019·Nature Communications·Celia Lozano, Clemens Bechinger
May 3, 2019·Communications Biology·Gail SingerCornelis J Weijer
Dec 11, 2019·Nature Communications·Shou-Wen Wang, Lei-Han Tang
Nov 15, 2020·Science Advances·K KaminoT S Shimizu
Jan 12, 2020·Communications Biology·Gail SingerCornelis J Weijer
Apr 22, 2021·Molecular Biology of the Cell·Dennis BotmanBas Teusink
Sep 10, 2021·Frontiers in Neural Circuits·Cezar BorbaWilliam C Smith

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