Folic acid administration prevents ouabain-induced hyperlocomotion and alterations in oxidative stress markers in the rat brain

Bipolar Disorders
Patrícia S BrocardoAna Lúcia S Rodrigues

Abstract

Bipolar disorder (BD) is a chronic, prevalent, and highly debilitating psychiatric illness. Folic acid has been shown to have antidepressant-like effects in preclinical and clinical studies and has also been suggested to play a role in BD. The present work investigates the therapeutic value of folic acid supplementation in a preclinical animal model of mania induced by ouabain. Male Wistar rats were treated twice daily for seven days with folic acid (10, 50, and 100 mg/kg, p.o.) or the mood stabilizer lithium chloride (LiCl) (45 mg/kg, p.o.). One day after the last dose was given, the animals received an i.c.v. injection of ouabain (10 microM), a Na(+),K(+)-ATPase-inhibiting compound. Locomotor activity was assessed in the open-field test. Thiobarbituric acid-reactive substance (TBARS) levels, glutathione peroxidase (GPx), and glutathione reductase (GR) activities were measured in the cerebral cortex and hippocampus. Ouabain (10 microM, i.c.v.) significantly increased motor activity in the open-field test, and seven days of pretreatment with folic acid (50 mg/kg, p.o.) or LiCl (45 mg/kg, p.o.) completely prevented this effect. Ouabain treatment elicited lipid peroxidation (increased TBARS levels) and reduced GPx activity in the...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jun 1, 1992·The American Journal of Clinical Nutrition·J F GregoryJ J Cerda
Jul 1, 1990·Journal of Affective Disorders·M W CarneyB Toone
Jan 1, 1986·Journal of Affective Disorders·A CoppenC Swade
Jan 1, 1985·Methods in Enzymology·I Carlberg, B Mannervik
Sep 1, 1988·Archives of Biochemistry and Biophysics·E L StokstadJ N Keating
Jul 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·A Coppen, M T Abou-Saleh
Jan 1, 1981·Methods in Enzymology·A Wendel
Feb 15, 1995·Biological Psychiatry·R S el-Mallakh, R J Wyatt
Sep 1, 1994·The New England Journal of Medicine·L H Price, G R Heninger
Jan 1, 1993·Neuropsychobiology·T Okuma
Sep 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·R S el-MallakhR S Levy
Dec 1, 1996·Nutrition Reviews·T Bottiglieri
May 1, 1997·Molecular and Chemical Neuropathology·R LiR S Levy
Feb 28, 1998·Journal of Affective Disorders·C I HasanahS M Razali
May 30, 1998·Journal of Neuroscience Methods·T SaitoT Nemoto
Jan 1, 1990·Behavioural Pharmacology·B.A. Ellenbroek, A.R. Cools
Jun 8, 2001·Free Radical Biology & Medicine·R JoshiT Mukherjee
Apr 30, 2002·Cell Biochemistry and Function·Murat KulogluNadire Cinkilinc
Apr 29, 2003·The Journal of Clinical Psychiatry·Joseph R CalabreseKaren D Wagner
Oct 4, 2003·Bipolar Disorders·Rif S El-MallakhRobert S Levy
Oct 25, 2003·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·F A MalekV Bienengräber
Dec 3, 2003·Neural Plasticity·Sheila E Henderson, Leslie Henderson
Jan 28, 2004·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Paula Garcia ChiarelloHelio Vannucchi
Mar 9, 2004·Progress in Lipid Research·Y DotanI Pinchuk
Apr 13, 2004·International Clinical Psychopharmacology·M Erkan OzcanOmer Akyol
Dec 8, 2004·Life Sciences·Rodrigo Machado-VieiraLuis Valmor C Portela
Jan 11, 2005·Neurotoxicity Research·A BoldyrevA Makhro
Jan 27, 2005·Journal of Psychopharmacology·Alec Coppen, Christina Bolander-Gouaille
Mar 31, 2005·Nutrition·Terken BaydarGonul Sahin
May 26, 2005·JAMA : the Journal of the American Medical Association·David J Kupfer
Aug 20, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Teodoro Bottiglieri
Jan 24, 2006·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Haluk Asuman SavasOmer Akyol
Jan 31, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cristiane MattéAngela T S Wyse
Mar 23, 2006·Journal of Psychopharmacology·Allan H Young, James I Newham
May 16, 2006·Bipolar Disorders·Benício Noronha FreyFlávio Kapczinski
Jul 4, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rif S El-MallakhRobert S Levy
Jul 25, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Benício N FreyFlávio Kapczinski
Jul 25, 2006·American Journal of Physiology. Heart and Circulatory Physiology·David J KennedyJoseph I Shapiro

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Citations

Jan 5, 2014·European Journal of Pharmacology·Marta GazalManuella P Kaster
Nov 8, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ajaykumar N SharmaJoao Quevedo
Sep 25, 2012·Journal of Psychiatric Research·Fernando V GhedimAlexandra I Zugno
Mar 31, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·César Augusto BrüningCristina Wayne Nogueira
Jan 10, 2012·Pharmacology, Biochemistry, and Behavior·Josiane BudniAna Lúcia S Rodrigues
Dec 17, 2014·Frontiers in Endocrinology·Anastasia Hodes, David Lichtstein
Jul 10, 2016·Bipolar Disorders·Anastasia HodesDavid Lichtstein
Dec 7, 2013·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Samira S ValvassoriJoão Quevedo
Nov 20, 2019·International Clinical Psychopharmacology·Hossein Sanjari MoghaddamShahin Akhondzadeh
Dec 7, 2013·Toxicology and Industrial Health·Mustafa YilmazOytun Erbas
Aug 9, 2018·International Journal of Molecular Sciences·David LichtsteinAnastasia Hodes
Jul 22, 2018·Molecular Neurobiology·Gustavo C Dal-PontSamira S Valvassori
Dec 29, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Garima SharmaHyoung-Chun Kim
Jun 1, 2021·Journal of Psychiatric Research·Luiz K S KanazawaRoberto Andreatini
Aug 7, 2021·Behavioural Brain Research·Josiane BudniAna Lúcia S Rodrigues

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