Folic acid and methionine in the prevention of teratogen-induced congenital defects in mice

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Daria CipolloneRita Businaro

Abstract

Periconceptional supplementation with multivitamins containing folic acid reduces the risk of congenital malformations. We have previously investigated the effect on the murine development of a multiple retinoic acid competitive antagonist, Bristol-Myers-Squibb 189453, showing that treated fetuses were affected with heart defects, thymus aplasia or hypoplasia, and severe anomalies of the central nervous system. Hereby, we analyzed the effects of nutritive therapy involving folic acid and methionine on teratogen-induced congenital defects in mice. A total of 132 outbred CD1 litters were studied. Pregnant mice were divided into four experimental groups, and an oral supplementation of H(2)O or folic acid, or methionine, or folic acid+methionine was administered from 0.5 days postcoitum until the end of pregnancy. At 7.5 days postcoitum, mice from all these groups were administered Bristol-Myers-Squibb 189453 to induce the teratogenic effect. At the end of pregnancy, fetuses were dissected and tissues were analyzed by histology and flow cytometric assays. Folic acid reduces congenital heart diseases from 81.3% to 64.8%, neural tube defects from 20.3% to 3.7%, and thymus abnormalities from 98.4% to 27.8%, restoring a normal number o...Continue Reading

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Citations

Nov 12, 2015·Developmental Biology·Anthony-Samuel LaMantiaAnastas Popratiloff
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·M Elizabeth Ross
Nov 26, 2010·Journal of Cardiovascular Medicine·Daria CipolloneBruno Marino
Apr 20, 2012·Prenatal Diagnosis·Laurent Mandelbrot
May 5, 2018·Journal of Cardiovascular Development and Disease·Paolo VersacciBruno Marino
Jan 26, 2021·Frontiers in Behavioral Neuroscience·Kai CraenenMohammed Abderrafi Benotmane

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