Folic acid-cysteamine modified gold nanoparticle as a nanoprobe for targeted computed tomography imaging of cancer cells

Materials Science & Engineering. C, Materials for Biological Applications
Sara KhademiHossein Ghadiri

Abstract

Development of various cost-effective multifunctional nanoprobes for efficient targeted molecular imaging of tumors remains a great challenge in medicine. Herein, we report a simple method of forming folic acid-targeted multifunctional gold nanoparticles via cost-effective cysteamine as a template for tumor molecular computed tomography (CT) imaging technique. The formed multifunctional cysteamine-folic acid conjugated gold nanoparticles (FA-Cys-AuNPs) were characterized via different techniques. Colony assay, hematoxylin and eosin (H&E), MTT, and flow cytometry analysis were used to evaluate the cytocompatibility of the particles. We showed that the formed FA-Cys-AuNPs with an Au core size of ~15 nm are non-cytotoxic in a given concentration range and revealed greater X-ray attenuation intensity than iodine-based contrast agent under the same concentration of the active element. At 80 kVp, FA-Cys-AuNPs enable 1.77-times greater contrast per unit mass compared with iodine at a concentration of 2000 μg/ml, and importantly, the developed FA-Cys-AuNPs can be used as a contrast media for targeted CT imaging of folic acid receptor-expressing cancer cells in vitro. CT values of the targeted cells were 2-times higher than that of non-...Continue Reading

Citations

May 23, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Jessica C HsuDavid P Cormode
Jul 19, 2019·Micromachines·Carmen J GilVahid Serpooshan
Feb 2, 2019·Current Medicinal Chemistry·Mário FernandesAndreia C Gomes
Dec 8, 2019·IET Nanobiotechnology·Sara KhademiHossein Ghadiri
Jan 7, 2021·Journal of Applied Clinical Medical Physics·Michael OumanoHengyong Yu
Jan 17, 2021·International Journal of Molecular Sciences·Bartosz F GrześkowiakRadosław Mrówczyński
Aug 14, 2020·International Journal of Biological Macromolecules·Arokia Vijaya Anand MariadossMyeong-Hyeon Wang
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Vesna V VodnikBranka Šošić-Jurjević
Jun 14, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Michael Oumano, Hengyong Yu
Mar 18, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Tingting XiaoXiangyang Shi

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