PMID: 8968013Dec 18, 1996Paper

Folic acid fortification of the food supply. Potential benefits and risks for the elderly population

JAMA : the Journal of the American Medical Association
K L TuckerJ Selhub

Abstract

To estimate the potential benefits and risks of food folic acid fortification for an elderly population. Benefits are expected through the improvement of folate and homocysteine status, but there is also a risk of masking or precipitating clinical manifestations related to vitamin B12 deficiency with increasing exposure to folic acid. Cross-sectional analysis, with projected change at various levels of folic acid fortification. Participants in the Framingham Heart Study original cohort. A total of 747 subjects aged 67 to 96 years who both completed usable food frequency questionnaires and had blood concentrations of B vitamins and homocysteine measured. Projected blood folate and homocysteine concentrations and combined high folate intake and low plasma vitamin B12 concentration. Percentages of this elderly population with folate intake below 400 microg/d are projected to drop from 66% at baseline to 49% with 140 microg of folate per 100 g of cereal-grain product, to 32% with 280 microg, to 26% with 350 microg, and to 11% with 700 microg. Percentages with elevated homocysteine concentrations (>14 micromol/L) are projected to drop from 26% at baseline to 21% with 140 microg of folate per 100 g, to 17% with 280 microg, to 16% wit...Continue Reading

Citations

May 25, 2005·Clinics in Geriatric Medicine·Veena K Ranganath, Daniel E Furst
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·B N Ames
May 14, 2003·BMJ : British Medical Journal·David S WaldNicholas J Wald
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·B C BlountB N Ames
Jul 2, 2008·Public Health Nutrition·Tanya Gk BentleyKaren M Kuntz
Mar 2, 2002·Progress in Cardiovascular Nursing·Cindy J Warren
Dec 16, 1998·The British Journal of Nutrition·G HornstraP M Verschuren
Feb 11, 2000·Annals of the New York Academy of Sciences·B N Ames
Oct 3, 1999·Journal of the American Academy of Nurse Practitioners·C KellerC Mobley
Aug 18, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R MorettiG Cazzato
Mar 24, 1998·Annual Review of Medicine·H RefsumS E Vollset
Oct 15, 1998·The New England Journal of Medicine·L B Russell
Apr 16, 1998·The New England Journal of Medicine·G P Oakley
May 13, 1999·The New England Journal of Medicine·P F JacquesI H Rosenberg
Feb 18, 1999·Toxicology Letters·B N Ames
Jan 31, 2003·Annals of Neurology·Carole DufouilChristophe Tzourio
Sep 26, 1997·Pediatric Annals·J W Buehler, J Mulinare
Dec 8, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jeljer HoekstraNynke de Jong
Oct 19, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Katherine L Tucker
Mar 21, 2007·Rheumatic Diseases Clinics of North America·Veena K Ranganath, Daniel E Furst
Mar 1, 2003·Clinics in Geriatric Medicine·Karin A JohnsonKaren Funderburg
Sep 15, 1998·Journal of the American Geriatrics Society·F A Lederle
Aug 5, 2005·Journal of Pharmacological Sciences·Sherifa A Hamed, Toshitaka Nabeshima
Aug 17, 1999·Current Opinion in Cardiology·S Guthikonda, W G Haynes
Apr 7, 1999·Current Opinion in Cardiology·P W Wilson
Mar 21, 1998·Current Opinion in Lipidology·P VerhoefE B Rimm
Mar 14, 2013·Journal of Perinatal Medicine·Rima ObeidKlaus Pietrzik
Dec 29, 2000·Current Opinion in Obstetrics & Gynecology·S A Ali, D L Economides
Oct 7, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Susanne H KirschRima Obeid
Aug 31, 2001·European Journal of Clinical Nutrition·V M FloodG L Rubin
Mar 12, 2002·Biological Research for Nursing·R Williamson
Nov 11, 2003·The Journal of Nutrition·Xiang GaoKatherine L Tucker
Apr 24, 2004·Stroke; a Journal of Cerebral Circulation·Wael K Al-DelaimyJoAnn E Manson
May 7, 2013·Annual Review of Nutrition·Katherine L TuckerJose M Ordovas
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·S R LentzD D Heistad

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