Folic acid supplementation improves microvascular function in older adults through nitric oxide-dependent mechanisms.

Clinical Science
Anna E StanhewiczW Larry Kenney

Abstract

Older adults have reduced vascular endothelial function, evidenced by attenuated nitric oxide (NO)-dependent cutaneous vasodilatation. Folic acid and its metabolite, 5-methyltetrahydrofolate (5-MTHF), are reported to improve vessel function. We hypothesized that (i) local 5-MTHF administration and (ii) chronic folic acid supplementation would improve cutaneous microvascular function in ageing through NO-dependent mechanisms. There were two separate studies in which there were 11 young (Y: 22 ± 1 years) and 11 older (O: 71 ± 3 years) participants. In both studies, two intradermal microdialysis fibres were placed in the forearm skin for local delivery of lactated Ringer's solution with or without 5 mM 5-MTHF. Red cell flux was measured by laser-Doppler flowmetry. Cutaneous vascular conductance [CVC=red cell flux/mean arterial pressure] was normalized as percentage maximum CVC (%CVCmax) (28 mM sodium nitroprusside, local temperature 43°C). In study 1 after CVC plateaued during local heating, 20 mM NG-nitro-L-arginine methyl ester (L-NAME) was perfused at each site to quantify NO-dependent vasodilatation. The local heating plateau (%CVCmax: O = 82 ± 3 vs Y = 96 ± 1, P = 0.002) and NO-dependent vasodilatation (%CVCmax: O = 26 ± 6% v...Continue Reading

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Citations

May 18, 2016·The British Journal of Nutrition·Billie K AlbaLacy M Alexander
Dec 16, 2016·Nutrition Reviews·Anna E Stanhewicz, W Larry Kenney
Jul 14, 2017·Journal of Neurophysiology·Jody L Greaney, W Larry Kenney
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Aug 8, 2018·European Journal of Applied Physiology·Anna OueYoshimitsu Inoue
Jul 18, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S Tony Wolf, W Larry Kenney
Feb 24, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anna E StanhewiczW Larry Kenney
Aug 25, 2020·European Journal of Nutrition·Eva-Maria Navarrete-MuñozManoli García-de-la-Hera
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Jan 2, 2021·Frontiers in Public Health·Yacong BoZengli Yu
Nov 14, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Shumpei FujieMotoyuki Iemitsu

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