Folic acid supplementation in pregnancy to prevent preterm birth: a systematic review and meta-analysis of randomized controlled trials

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Gabriele Saccone, Vincenzo Berghella

Abstract

Folic acid (FA) may have a role in the prevention of pregnancy complications. However, the efficacy of FA supplementation in reducing the risk of preterm birth (PTB) is still unclear. The aim of this systematic review with meta-analysis was to evaluate the efficacy of folic acid supplementation during pregnancy to prevent preterm birth (PTB). The research protocol was designed a priori, defining methods for searching the literature in electronic databases, including and examining articles, and extracting and analyzing data. We included all randomized trials (RCTs) of asymptomatic singleton gestations without prior PTB who were randomized to prophylactic treatment with either FA supplementation or control (placebo or no treatment). The primary outcome was the incidence of PTB <37 weeks. Five randomized trials including 5,332 asymptomatic singleton gestations without prior PTB were included in the analysis. Women who received FA supplementation had a similar rate of PTB <37 weeks (22.6% vs 22.9%; RR 0.99, 95% CI 0.82-1.18), PTB<34 weeks (7.1% vs 8.7%; RR 0.77, 95% CI 0.55-1.09) and of preterm premature rupture of membranes (2.4% vs 2.9%; RR 0.81, 95% CI 0.44-1.50) compared with control group. Regarding neonatal outcome we found n...Continue Reading

References

Jan 1, 1969·Acta Obstetricia Et Gynecologica Scandinavica·B M Hibbard, E D Hibbard
Sep 1, 1971·The Journal of Obstetrics and Gynaecology of the British Commonwealth·J FletcherD N Menzies
Jan 3, 1970·British Medical Journal·N BaumslagJ Metz
Feb 1, 1968·The Journal of Obstetrics and Gynaecology of the British Commonwealth·T EdelsteinJ Metz
May 18, 1968·British Medical Journal·I ChanarinJ Perry
Apr 1, 1968·The Journal of Obstetrics and Gynaecology of the British Commonwealth·A F FlemingN C Allan
Nov 9, 1968·British Medical Journal·M L Willoughby, F G Jewell
Jun 1, 1981·British Journal of Obstetrics and Gynaecology·D J TaylorT Lind
May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews
Aug 2, 2007·Obstetrics and Gynecology·Catherine Y Spong
Dec 7, 2007·Obstetrics and Gynecology·Russel D Jelsema
Jul 23, 2008·Archives of Disease in Childhood·Penelope S Nestel, Alan A Jackson
Apr 17, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Parul ChristianSanu Maiya Dali
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Jul 27, 2010·Reproductive Toxicology·Nina H van MilRégine P M Steegers-Theunissen
Jan 29, 2011·The Journal of Obstetrics and Gynaecology Research·Atsuo KondoYoichi Shimosuka
May 1, 2012·American Journal of Obstetrics and Gynecology·UNKNOWN Society for Maternal-Fetal Medicine Publications Committee, with assistance of Vincenzo Berghella
Jan 17, 2014·The New England Journal of Medicine·Jay D Iams
May 9, 2014·The New England Journal of Medicine·Jay D Iams
May 24, 2014·Lancet·Zulfiqar A BhuttaUNKNOWN Lancet Every Newborn Study Group
Feb 1, 2015·American Journal of Obstetrics and Gynecology·Amanda RomanAdiel Fleischer
Mar 3, 2015·Obstetrics and Gynecology·Gabriele Saccone, Vincenzo Berghella
Mar 12, 2015·American Journal of Obstetrics and Gynecology·Gabriele Saccone, Vincenzo Berghella
Jun 3, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G SacconeP Martinelli
Sep 19, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gabriele SacconeVincenzo Berghella
Nov 3, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Xiaolin HuaShi Wu Wen

❮ Previous
Next ❯

Citations

Jan 21, 2014·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Brett M Jakaitis, Patricia W Denning
Apr 12, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Gabriele SacconeVincenzo Berghella
Jun 16, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rupsa C BoeligVincenzo Berghella
Mar 16, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·V BerghellaG Saccone
Oct 16, 2018·Minerva ginecologica·Rossana Di SarnoGabriele Saccone
Dec 21, 2017·JAMA : the Journal of the American Medical Association·Gabriele SacconeUNKNOWN Italian Preterm Birth Prevention (IPP) Working Group
Dec 8, 2017·Maternal Health, Neonatology and Perinatology·Manal E SharifIshag Adam
Feb 8, 2018·Age and Ageing·Patrick Alexander WachholzPaulo José Fortes Villas-Boas
Oct 18, 2019·Journal of Perinatal Medicine·Buse GülerMurat Alan
Jan 25, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Giovanni NazzaroMariavittoria Locci
Jan 6, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Reshama NavatheVincenzo Berghella
Dec 19, 2019·Frontiers in Neuroscience·Bingbing LiChanglian Zhu
Jun 26, 2017·BMC Nutrition·Samiksha SinghGudlavalleti Venkata Satyanarayana Murthy
Jan 2, 2021·Frontiers in Public Health·Yacong BoZengli Yu
Jan 12, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Pietro D'AlessandroGabriele Saccone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved