Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors

Nanomedicine : Nanotechnology, Biology, and Medicine
Ana LoureiroArtur Cavaco-Paulo

Abstract

Folic Acid (FA)-tagged protein nanoemulsions were found to be preferentially internalized on B-cell lymphoma cell line (A20 cell line), which, for the first time, is reported to express folate receptor (FR)-alpha. Carbon monoxide releasing molecule-2 (CORM-2) was incorporated in the oil phase of the initial formulation. FA-functionalized nanoemulsions loaded with CORM-2 exhibited a considerable antitumor effect and an increased survival of BALB/c mice bearing subcutaneous A20 lymphoma tumors. The developed nanoemulsions also demonstrated to be well tolerated by these immunocompetent mice. Thus, the results obtained in this study demonstrate that FA-tagged protein nanoemulsions can be successfully used in cancer therapy, with the important ability to delivery drugs intracellularly. In this research, the authors developed folic acid tagged nanoemulsions containing a carbon monoxide releasing protein molecule for targeted cancer cell treatment. In-vitro and in-vivo experiments showed efficacy against B-cell lymphoma cells. The same nanocarrier platform could be applied to other tumor cells expressing folate receptors on the cell surface.

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Citations

Mar 22, 2016·Trends in Biotechnology·Madalena MartinsArtur Cavaco-Paulo
Oct 21, 2016·Applied Microbiology and Biotechnology·Ana TinocoArtur Cavaco-Paulo
Sep 18, 2015·The Journal of Physiology·Sara R OliveiraHelena L A Vieira
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Aug 31, 2018·Bioinorganic Chemistry and Applications·Aiten IsmailovaIan S Butler
Mar 14, 2017·Oxidative Medicine and Cellular Longevity·Malamati KourtiJun Cai
Nov 26, 2020·Scientific Reports·Chien-Cheng HuangHow-Ran Guo
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Feb 12, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Lingling KongTuomas P J Knowles

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