PMID: 28529305May 23, 2017Paper

Folic Acid-Targeted Etoposide Cubosomes for Theranostic Application of Cancer Cell Imaging and Therapy

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Yong TianLingyi Sun

Abstract

BACKGROUND The aim of this study was to develop a novel Poloxamer-based drug delivery system featuring a tumor-targeting folate moiety, which was expected to provide better targeting properties and therapeutic effects compared with the traditional cubosomes (Cubs). MATERIAL AND METHODS Both folate-modified Cubs containing etoposide (ETP-Cubs-FA) and normal cubic nanoparticles loaded with etoposide (ETP-Cubs) were prepared through the fragmentation of bulk gels under the homogenization condition of 1500 bar, and a mean particle size of around 180 nm was obtained with a narrow size distribution. The cubosomes were further characterized by differential scanning calorimetry (DSC) and Polarized light microscopy (PLM). The release of ETP in vitro from these nanoparticles was found to be 82.5% at 36 h, showing a sustained release property compared with the free drug administration. RESULTS Folate-modified cubosomes exhibited best anti-proliferative activity followed by normal cubosomes and the free drug. A further cell uptake study of Rhodamine B-loaded Cubs-FA (Rh-B-Cubs-FA) showed a marked increase of cellular accumulation compared with free Rh-B and Rh-B-loaded Cubs (Rh-B-Cubs). In vivo Rh-B-based tumor imaging demonstrated that Cu...Continue Reading

References

Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexander V KabanovValery Yu Alakhov
Jul 21, 2004·Colloids and Surfaces. B, Biointerfaces·Warunee LeesajakulTetsurou Handa
Aug 11, 2005·Nano Letters·Justas BarauskasFredrik Tiberg
Feb 3, 2006·International Journal of Cancer. Journal International Du Cancer·Linda E Kelemen
Jun 5, 2008·Cancer Metastasis Reviews·Emanuela I Sega, Philip S Low
Aug 19, 2008·International Journal of Biological Macromolecules·Ajun WanHuili Li
Nov 27, 2009·Journal of Colloid and Interface Science·François MullerOtto Glatter
Nov 1, 2012·Indian Journal of Pharmaceutical Sciences·J J ParmarMala D Menon
Mar 26, 2013·International Journal of Pharmaceutics·J C BodeH Bunjes
May 13, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Claudia CaltagironeSergio Murgia
Jul 1, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Nicole ByeBenjamin W Muir
Mar 10, 2015·Expert Opinion on Drug Delivery·Terence E HartnettKatharina Ladewig
Apr 2, 2015·Colloids and Surfaces. B, Biointerfaces·Sergio MurgiaClaudia Caltagirone
Aug 22, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Valeria MeliSergio Murgia
Sep 6, 2015·Chemistry and Physics of Lipids·Antonella RosaAngela Maria Falchi
Sep 9, 2015·Drug Design, Development and Therapy·Xinsheng PengChuanbin Wu
Oct 30, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Simone AleandriEhud M Landau
Oct 31, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jian-Chun LiJi-Fu Hao
Feb 2, 2016·International Journal of Pharmaceutics·Nazik A ElgindySalma M Mohyeldin
May 11, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hanisah AzhariShakila B Rizwan
Jul 19, 2016·Journal of Colloid and Interface Science·Ibrahim Birma BwatanglangSwee Keong Yeap
Oct 25, 2016·Journal of Colloid and Interface Science·Jing LiuYuxia Luan

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Citations

Apr 24, 2019·Nanomaterials·Beatriz García-PinelJuan M López-Romero
Apr 30, 2020·International Journal of Nanomedicine·Heshu Sulaiman RahmanNoorjahan Banu Alitheen
Oct 30, 2020·International Journal of Nanomedicine·Dorota K FlakJanka Held-Feindt
Apr 2, 2021·International Journal of Nanomedicine·Hairong WangJianchun Li
May 18, 2021·Acta Pharmaceutica Sinica. B·Anan Yaghmur, Huiling Mu
Nov 29, 2017·Bioconjugate Chemistry·Nicolas AlcarazBen J Boyd
Nov 16, 2021·Drug Development and Industrial Pharmacy·Chunling TianChu Xiaoqin

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