Folic Acid, Vitamin B6, and Vitamin B12 in Combination and Age-Related Cataract in a Randomized Trial of Women

Ophthalmic Epidemiology
W G ChristenJoann E Manson

Abstract

To examine the incidence of cataract and cataract extraction in a trial of folic acid and vitamins B6 and B12. In a randomized, double-masked, placebo-controlled trial, 5442 female health professionals aged 40 years or older with preexisting cardiovascular disease (CVD) or three or more CVD risk factors were randomly assigned to receive a combination of folic acid (2.5 mg/day), vitamin B6 (50 mg/day), and vitamin B12 (1 mg/day), or placebo. A total of 3925 of these women did not have a diagnosis of cataract at baseline and were included in this analysis. The primary endpoint was age-related cataract, defined as an incident age-related lens opacity, responsible for a reduction in best-corrected visual acuity to 20/30 or worse, based on self-report confirmed by medical record review. Extraction of incident age-related cataract was a secondary endpoint of the trial. During an average of 7.3 years of treatment and follow-up, 408 cataracts and 275 cataract extractions were documented. There were 215 cataracts in the combination treatment group and 193 in the placebo group (hazard ratio, HR, 1.10, 95% confidence interval, CI, 0.90-1.33; p = 0.36). For the secondary endpoint of cataract extraction, there were 155 in the combination tr...Continue Reading

References

Nov 1, 1979·Nutrition Reviews·G E Bunce
Aug 26, 1992·JAMA : the Journal of the American Medical Association·W G ChristenC H Hennekens
Aug 26, 1992·JAMA : the Journal of the American Medical Association·S E HankinsonM J Stampfer
Mar 1, 1992·Archives of Ophthalmology·R J Glynn, B Rosner
Jan 1, 1991·Age and Ageing·H Gerster
Jul 1, 1988·The American Journal of Clinical Nutrition·P F JacquesJ A Sadowski
Mar 1, 1987·International Journal of Epidemiology·C Borland, T Higenbottam
Jan 1, 1973·Archives of Ophthalmology·F Ederer
Nov 1, 1995·Archives of Ophthalmology·S WestN M Bressler
Sep 1, 1995·Archives of Ophthalmology·R J GlynnC H Hennekens
Jan 1, 1995·Survey of Ophthalmology·S K West, C T Valmadrid
Feb 15, 1995·American Journal of Epidemiology·J A Mares-PerlmanS M Shoff
Sep 1, 1993·Archives of Ophthalmology·R D SperdutoJ Y Li
Jan 1, 1996·Annals of Epidemiology·A TavaniC La Vecchia
Apr 4, 1998·Acta Ophthalmologica Scandinavica·J M TeikariO P Heinonen
Nov 4, 1998·Journal of Epidemiology and Community Health·J M TeikariO Heinonen
Jun 13, 2000·Circulation Research·E S StroesT J Rabelink
Aug 6, 2000·JAMA : the Journal of the American Medical Association·W G ChristenJ E Manson
Oct 6, 2000·The American Journal of Medicine·A van der Vliet, C E Cross
Nov 7, 2000·International Ophthalmology Clinics·A Taylor
Nov 7, 2000·International Ophthalmology Clinics·S Y Wu, M C Leske
Dec 2, 2000·The American Journal of Clinical Nutrition·D A SchaumbergC H Hennekens
Jul 5, 2001·American Journal of Ophthalmology·M KuzniarzV M Flood
Jul 27, 2001·Archives of Ophthalmology·P F JacquesA Taylor
Jul 20, 2001·Current Eye Research·Y ItoM Tomohiro
Oct 6, 2001·Progress in Retinal and Eye Research·L Schmetterer, K Polak
Dec 26, 2001·The British Journal of Nutrition·E NakanoH J Powers
Feb 28, 2002·The American Journal of Clinical Nutrition·Allen TaylorWalter C Willett
Sep 26, 2002·Epidemiology·K J Rothman
Feb 19, 2003·Experimental Eye Research·Kemal OrnekZeliha Büyükbingöl
Mar 6, 2003·Archives of Ophthalmology·William G ChristenCharles H Hennekens
Jan 9, 2004·Ophthalmology·John J McNeilHugh R Taylor
Dec 14, 2004·Ophthalmic Epidemiology·William ChristenJulie Buring
Jun 15, 2005·American Journal of Ophthalmology·Gerhard GarhöferLeopold Schmetterer
Oct 8, 2005·The American Journal of Clinical Nutrition·UNKNOWN Homocysteine Lowering Trialists' Collaboration
Aug 2, 2006·Experimental Eye Research·Chung-Jung Chiu, Allen Taylor
Sep 13, 2006·Archives of Ophthalmology·Adrienne WilliamsPaul P Lee
Mar 14, 2007·Free Radical Biology & Medicine·Eva M OlofssonAnders Behndig
Apr 21, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Shambhu D Varma, Kavita R Hegde
Dec 11, 2007·Ophthalmology·William G ChristenJulie E Buring
Mar 18, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Kirtan V TarwadiVaishali Agte

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Citations

Dec 23, 2016·Internal and Emergency Medicine·Chih-Yang HuangWei-Syun Hu
Oct 16, 2018·Current Opinion in Ophthalmology·Ruti Sella, Natalie A Afshari
May 30, 2019·Nutrients·Andrea J BraakhuisPaul J Donaldson

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