Follicle activation is a significant and immediate cause of follicle loss after ovarian tissue transplantation

Journal of Assisted Reproduction and Genetics
Zohar GavishD Meirow

Abstract

Extensive follicle loss has been demonstrated in ovarian grafts post transplantation, reducing their productivity and lifespan. Several mechanisms for this loss have been proposed, and this study aims to clarify when and how the massive follicle loss associated with transplantation of ovarian tissue graft occurs. An understanding of the mechanisms of follicle loss will pinpoint potential new targets for optimization and improvement of this important fertility preservation technique. Frozen-thawed marmoset (n = 15), bovine (n = 37), and human (n = 46) ovarian cortical tissue strips were transplanted subcutaneously into immunodeficient castrated male mice for 3 or 7 days. Histological (H&E, Masson's trichrome) analysis and immunostaining (Ki-67, GDF9, cleaved caspase-3) were conducted to assess transplantation-associated follicle dynamics, with untransplanted frozen-thawed tissue serving as a negative control. Evidence of extensive primordial follicle (PMF) activation and loss was observed already 3 days post transplantation in marmoset, bovine, and human tissue grafts, compared to frozen-thawed untransplanted controls (p < 0.001). No significant additional PMF loss was observed 7 days post transplantation. Recovered grafts of al...Continue Reading

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Citations

Jun 13, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Petra VukovićLidija Beketić-Orešković
Nov 17, 2019·Journal of Assisted Reproduction and Genetics·Rossella MasciangeloMarie-Madeleine Dolmans
Jul 11, 2020·Clinical Obstetrics and Gynecology·Leslie C Appiah
Aug 8, 2020·Endocrine Reviews·Johanne GrosboisIsabelle Demeestere
Sep 25, 2018·The Journal of Obstetrics and Gynaecology Research·Marie-Madeleine Dolmans, Diego D Manavella
Jul 18, 2019·Reproductive Medicine and Biology·Seido Takae, Nao Suzuki
Aug 21, 2019·Frontiers in Endocrinology·Marie-Madeleine DolmansCatherine Vander Linden
Jul 26, 2018·Journal of Assisted Reproduction and Genetics·Laura DettiIrene Peregrin-Alvarez
Oct 12, 2018·Journal of Molecular Histology·Rebeca Chávez-Genaro, Gabriel Anesetti
Jul 2, 2019·Clinical Medicine Insights. Reproductive Health·Charlotte SonigoMichael Grynberg
Jun 9, 2020·Molecular Reproduction and Development·Stine A LundingSusanne E Pors
Nov 14, 2019·International Journal of Molecular Sciences·Charlotte SonigoMichaël Grynberg
May 5, 2020·Frontiers in Endocrinology·Zeev Blumenfeld
Nov 1, 2018·Reproductive Medicine and Biology·Yasushi Takai
Aug 4, 2019·Journal of Assisted Reproduction and Genetics·Yann LocatelliM J Bertoldo
May 8, 2020·International Journal of Molecular Sciences·Erica SilvestrisAngelo Virgilio Paradiso
Oct 8, 2020·Journal of Assisted Reproduction and Genetics·Camille HossayMarie-Madeleine Dolmans
Oct 27, 2020·Frontiers in Cell and Developmental Biology·Yao ChenDonghui Huang
May 1, 2021·International Journal of Molecular Sciences·Kim Cat Tuyen Vo, Kazuhiro Kawamura
May 3, 2021·Fertility and Sterility·Marie-Madeleine DolmansClaus Yding Andersen
Dec 15, 2020·Trends in Molecular Medicine·Marie-Madeleine DolmansLuciana Cacciottola
Aug 14, 2021·Reproductive Biomedicine Online·Luciana CacciottolaMarie-Madeleine Dolmans

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