PMID: 8582957Jul 1, 1995Paper

Follicle stimulating hormone alone supports follicle growth and oocyte development in gonadotrophin-releasing hormone antagonist-treated monkeys

Human Reproduction
M B Zelinski-WootenR L Stouffer

Abstract

Both follicle stimulating hormone (FSH) and luteinizing hormone (LH) are proposed requirements for follicular growth and steroidogenesis; however, the role of LH in primate folliculogenesis is unclear. Follicular stimulation by recombinant human FSH (n = 5) with and without recombinant LH (1:1; n = 6) following 90 days of gonadotrophin-releasing hormone (GnRH) antagonist (Antide) treatment in macaques was evaluated. Human chorionic gonadotrophin (HCG) was administered when six follicles > or = 4 mm were observed. Oocytes were aspirated 27 h later and inseminated in vitro. Chronic Antide reduced serum oestradiol and bioactive LH to concentrations observed in hypophysectomized rhesus monkeys. Multiple follicular growth required a longer interval following recombinant FSH (12 +/- 1 days) than recombinant FSH+recombinant LH (9 +/- 0.2 days), but the total number of follicles/animal did not differ between groups. The day prior to HCG, oestradiol concentrations were 4-fold less following recombinant FSH compared to recombinant FSH+recombinant LH. With recombinant FSH, more oocytes completed meiosis to metaphase II (51%) and fertilized (89 +/- 5%) relative to recombinant FSH+recombinant LH (12 and 52 +/- 11% respectively). Follicular ...Continue Reading

Citations

Apr 30, 2005·Journal of Medical Primatology·Nobuhiko YoshimotoIkuo Hayasaka
Jan 26, 2006·Endocrine Reviews·Nick S MacklonBart C J M Fauser
Jul 30, 2018·Journal of Assisted Reproduction and Genetics·Israel OrtegaAntonio Pellicer
Jun 14, 2020·Journal of Assisted Reproduction and Genetics·Justin TanGary Nakhuda
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Aug 2, 2003·Biology of Reproduction·Shoukhrat M MitalipovDon P Wolf
Apr 23, 2002·Biology of Reproduction·Shoukhrat M MitalipovDon P Wolf
Jun 6, 2009·Journal of Medical Primatology·Stuart A MeyersJames W Overstreet
Apr 19, 2012·American Journal of Primatology·Yongchang ChenWeizhi Ji
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Jun 23, 2001·Biology of Reproduction·S M MitalipovD P Wolf
Jan 23, 1999·Biology of Reproduction·D P WolfM Zelinski-Wooten

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