Follicle-stimulating hormone (FSH) regulates the expression of FSH receptor messenger ribonucleic acid in cultured Sertoli cells and in hypophysectomized rat testis

Biology of Reproduction
S M MaguireM D Griswold

Abstract

FSH acts on Sertoli cells via interaction with a transmembrane receptor (FSHr). Control of expression of the receptor is surely a factor in the regulation of the action of FSH. The regulation of FSHr by FSH and testosterone was studied both in culture and in vivo. Sertoli cells from 18- to 20-day-old male rats were cultured in the presence of 25 ng/ml ovine (o) FSH. At 8 h after addition of FSH, expression of FSHr mRNA decreased significantly. Addition of FSH and actinomycin D to cells did not result in a further decrease in FSHr mRNA levels, suggesting that FSH does not alter turnover of FSHr mRNA. Treatment of cells with 40 ng/ml testosterone did not have any significant effect on the expression of FSHr mRNA. Hypophysectomy of 20-day-old male rats resulted in an increase in expression of FSHr mRNA as compared to that in sham-hypophysectomized animals. This increase was measured at 24 h posthypophysectomy and was maintained at 72 h after surgery. Injection of rats with 0.2 U oFSH at 48 h posthypophysectomy resulted in a reduction in FSHr mRNA when compared to the levels in hypophysectomized rats. Treatment with 2 mg testosterone propionate had no effect on FSHr mRNA levels. The findings confirm that FSH plays an important role...Continue Reading

Citations

Oct 15, 2011·BMC Research Notes·Deepthi TelikicherlaAkhilesh Pandey
Jul 13, 2013·The Journal of Clinical Endocrinology and Metabolism·Suman RiceHelen D Mason
Jan 24, 2013·Molecular Endocrinology·Stella TranDaniel J Bernard
May 23, 2002·Recent Progress in Hormone Research·Leslie L Heckert, Michael D Griswold
Jun 30, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·William H Walker, Jing Cheng
Sep 18, 2007·Molecular Reproduction and Development·Gersende Maugars, Monika Schmitz
Feb 6, 2004·The Journal of Biological Chemistry·M Joseph ScobeyWilliam H Walker

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