Follicle-stimulating hormone increases primordial follicle reserve in mature female hypogonadal mice

The Journal of Endocrinology
Charles M AllanDavid J Handelsman

Abstract

Ovarian primordial follicle reserve is considered hormonally independent or subject to depletion by FSH-driven follicle recruitment. To explore specific in vivo effects of FSH on early follicle populations in the absence of luteinizing hormone (LH) activity, we examined mature hypogonadal (hpg), gonadotrophin-deficient mice expressing transgenic (tg) human FSH. Sustained expression of tg-FSH (5.3 +/- 0.3 IU/l) increased ovary weights fourfold and significantly elevated total primordial follicle numbers twofold in tg-FSH hpg (4209 +/- 457) relative to non-tg hpg (2079 +/- 391) and wild-type (2043 +/- 195) age-matched ovaries. Absolute primary follicle numbers in tg-FSH hpg ovaries were similar to non-tg hpg and wild-type ovaries. Furthermore, tg-FSH quantitatively increased secondary and antral follicles in hpg ovaries to numbers equivalent to wild-type, but did not induce ovulation, indicating a selective FSH response without LH. Circulating inhibin B and inhibin A levels were significantly increased in tg-FSH hpg females compared with hpg controls, and inhibin B correlated with antral number, consistent with FSH-driven antral follicle formation. These findings revealed that sustained pituitary-independent FSH activity, in the ...Continue Reading

Citations

Apr 13, 2011·Reviews in Endocrine & Metabolic Disorders·Hellevi PeltoketoSusana B Rulli
May 12, 2011·Reproduction, Fertility, and Development·D J Handelsman
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Charles M AllanMarkus J Seibel
Feb 9, 2011·Reproductive Biology and Endocrinology : RB&E·Norbert GleicherDavid H Barad
Nov 3, 2011·PloS One·Romain DacquinIrma Machuca-Gayet
Oct 2, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Eileen A McLaughlin, Skye C McIver
Oct 15, 2014·Journal of Molecular Endocrinology·Annu MakkerAbbas Ali Mahdi
Jun 29, 2012·Scientific Reports·Jinkyung KimJung Ho Je
Sep 29, 2018·Minerva ginecologica·Kamila SzymańskaAdolfo Rivero-Müller
Jul 11, 2009·Endocrine Reviews·Deepak Adhikari, Kui Liu
Jun 2, 2007·Endocrinology·Kirsten J McTavishCharles M Allan
Aug 8, 2020·Endocrine Reviews·Johanne GrosboisIsabelle Demeestere
Feb 23, 2019·Frontiers in Endocrinology·Rosemary McDonaldT Rajendra Kumar
May 22, 2018·Best Practice & Research. Clinical Endocrinology & Metabolism·Sara Babcock GilbertT Rajendra Kumar
May 1, 2021·International Journal of Molecular Sciences·Kim Cat Tuyen Vo, Kazuhiro Kawamura

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