Follicle-stimulating hormone promotes the growth of human epithelial ovarian cancer cells through the protein kinase C-mediated system

Cancer Letters
K OhtaniK Satoh

Abstract

We have previously described that follicle-stimulating hormone (FSH) stimulated the growth of human epithelial ovarian cancer tissues and cells. In order to determine the signaling pathway on FSH action in ovarian cancer, we used an epithelial ovarian cancer cell line (HRA line) which constitutively FSH receptors (FSHRs). FSH significantly increased cell proliferation (230.1 +/- 20.5%, P < 0.05) and (3)H-thymidine uptake (443.5 +/- 35.1%, P < 0.01). 1-(5-Isoquinolinesulfonyl)-2-methyipiperazine (H7, 1 5 nM), staurosponine (STR, 5 nM) and calphostin C (5 nM), specific protein kinase C (PKC) inhibitors, significantly suppressed the FSH-stimulated cell growth (120.2-140.2%, P < 0.05) and (3)H-thymidine uptake (140.5-173.9%, P < 0.05), whereas N-(2-guanidinoethyl)-5-isoquinoline-sulfon-amide (HA1004, l5 nM), which is a derivant of H7 and inhibits most of protein kinases except PKC, showed no effect on the FSH-stimulated cell growth and (3)H-thymidine uptake. A pretreatment with 12-0-tetradecanoylphorbol-13 acetate (TPA, 100 ng/ml) or STR (20 nM) significantly suppressed the subsequent FSH-stimulated cell growth (TPA; 152.3 +/-10.3%, STR; 160.4 +/- 15.9%, P < 0.05) and (3)H-thymidine uptake (TPA; 250.4 +/-18.3%, STR; 208.7 +/- 15.9%...Continue Reading

References

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Citations

Jul 29, 2003·Archives of Gynecology and Obstetrics·Anita Chudecka-GłazBarbara Kosmowska
Mar 17, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H ZhengS Fu
Oct 2, 2004·Oncology·Michael LahnThomas F Bumol
Jun 3, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Laura F PisaniFulvio Gandolfi
May 29, 2012·Cancer Letters·Inga Mertens-WalkerDeborah J Marsh
Aug 17, 2005·Reproductive Biomedicine Online·Chinmoy K Bose
Aug 30, 2005·Trends in Endocrinology and Metabolism : TEM·Jörg Gromoll, Manuela Simoni
Jun 5, 2007·Annales d'endocrinologie·A WunschM Simoni
May 18, 2010·Molecular and Cellular Endocrinology·Ilpo Huhtaniemi
Apr 28, 2007·Endocrine Reviews·Jung-Hye ChoiPeter C K Leung
Oct 31, 2006·Human Reproduction Update·Peter C K Leung, Jung-Hye Choi
Oct 12, 2018·Current Cancer Drug Targets·Zhiquan LiangHanqing Liu
Aug 3, 2021·The Kaohsiung Journal of Medical Sciences·Shen-Yao ZhangKe-Fang Dong

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