Abstract
The follicle-stimulating hormone (FSH) plays a central role in vertebrate reproduction, with the actions of FSH mediated by FSH receptors (FSHRs) on the granulosa cells of the ovary. The present study reports the cloning and characterization of FSHR in Chinese alligator, Alligator sinensis (caFSHR), and its tissue distribution and mRNA expression changes during the reproductive cycle. The mature protein of caFSHR displays typical features of the glycoprotein hormone receptor family, but also contains some remarkable differences when compared with other vertebrate FSHRs. The deduced amino acid sequence of the caFSHR shares identity of 85% with Chinese softshell turtle, 84-87% with birds, 77-78% with mammals, 67-73% with amphibians and 51-58% with fishes. Phylogenetic tree analysis of the FSHR amino acid sequence indicated that alligators cluster into the bird branch. Tissue expression analysis showed that caFSHR was not only expressed in the ovary, but also in the stomach, intestine, pancreas liver and oviduct at similar levels, while it was not detectable in heart, thymus or thyroid. Expression of caFSHR in the ovary is high in May (breeding prophase) and peaks in July during the breeding period, where it is maintained at high ...Continue Reading
References
Nov 16, 1992·Biochemical and Biophysical Research Communications·J GromollE Nieschlag
Dec 20, 1996·Molecular and Cellular Endocrinology·P J O'ShaughnessyW R Rajapaksha
Dec 31, 1997·Endocrine Reviews·M SimoniE Nieschlag
Jun 24, 1999·Molecular Endocrinology·M F LazariM Ascoli
Mar 4, 2000·Endocrine Reviews·U Gether
Aug 10, 2000·Molecular Endocrinology·S Y HsuA J Hsueh
Aug 22, 2001·Biology of Reproduction·R S KumarJ M Trant
Dec 26, 2001·Current Opinion in Structural Biology·B Kobe, A V Kajava
Mar 28, 2002·Physiological Reviews·Mariusz W SzkudlinskiBruce D Weintraub
Apr 23, 2002·Protein Science : a Publication of the Protein Society·Andrey V Kajava, Bostjan Kobe
May 30, 2003·The EMBO Journal·Guillaume SmitsSabine Costagliola
Mar 9, 2004·Trends in Biochemical Sciences·Gilbert VassartSabine Costagliola
Jun 18, 2004·General and Comparative Endocrinology·Ana P C BluhmMaria Fátima M Lazari
Sep 2, 2004·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Cheng-Hai Liu
Mar 14, 2007·Molecular and Cellular Endocrinology·Tomi PakarainenIlpo Huhtaniemi
Jun 5, 2007·Molecular and Cellular Endocrinology·Ana RochaManuel Carrillo
Aug 5, 2008·General and Comparative Endocrinology·Archana MinjV P Varshney
Dec 9, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Kwang Wook AnCheol Young Choi
Dec 14, 2011·General and Comparative Endocrinology·Brandon C MooreLouis J Guillette
May 15, 2012·General and Comparative Endocrinology·Y MinegishiG E E J M van den Thillart
Jun 1, 2012·Biology of Reproduction·François ChauvignéJoan Cerdà
Jul 31, 2012·Fish Physiology and Biochemistry·Wei J MuBao X Qi
Jun 29, 2013·Environmental Science & Technology·Kyunghee JiKyungho Choi
Jan 28, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Rui ZhangXiaobing Wu
Citations
May 21, 2015·International Journal of Molecular Sciences·Weimin WangTingfu Li
Nov 20, 2015·General and Comparative Endocrinology·Xue ZhuXiaobing Wu
May 24, 2016·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Ruidong ZhangXiaobing Wu
Jan 23, 2018·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Sheng-Zhou ZhangXiao-Bing Wu
Jul 19, 2020·Endocrine·Rossella CannarellaAldo E Calogero
Nov 11, 2020·BMC Genomics·Jian-Qing LinSheng-Guo Fang