Follicle Stimulating Hormone Receptor (FSHR) Polymorphisms and Polycystic Ovary Syndrome (PCOS)

Frontiers in Endocrinology
Joop S E Laven

Abstract

Polycystic ovary syndrome (PCOS) is the commonest endocrine abnormality in women of reproductive age typically presenting with chronic oligo- or anovulation, clinical, or biochemical hyperandrogenism and polycystic ovarian morphology (PCOM). Restoring mono-ovulation is the ultimate goal of ovulation induction and most women do respond to ovulation inducing agents causing their Follicle-stimulating hormone (FSH) levels to rise. Familial clustering and the results from twin studies strongly support an underlying genetic basis for PCOS. Recent Genome wide association studies (GWAS) have identified several genetic variants being genome wide significantly associated with PCOS. Amongst those are variants in or near the Luteinizing hormone (LH) and FSH receptor genes as well as a variant in the FSH-β gene. The aim of this review is to summarize the available evidence as to whether single nucleotide polymorphisms are able to modify the PCOS phenotype or whether they constitute a risk factor for the syndrome. Data on the role of FSHR polymorphisms in PCOS are conflicting. It seems that in large Chinese studies FSHR polymorphisms are not associated with either PCOS risk or with PCOS treatment outcome. However, in large scale studies in C...Continue Reading

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Citations

Oct 15, 2019·Annals of Pediatric Endocrinology & Metabolism·Ju Young Yoon, Chong Kun Cheon
Mar 3, 2020·Hormone Molecular Biology and Clinical Investigation·Chrysa PaschalidouDimitrios Loutradis
Sep 30, 2020·Cytotechnology·Zohreh HashemianAhmad Nasimian
Nov 20, 2019·Journal of Family Medicine and Primary Care·Sangeeta RaiRoyana Singh
Dec 1, 2020·The FEBS Journal·Antara A BanerjeeSmita D Mahale
Dec 21, 2021·Frontiers in Genetics·Abdessamad OuhrouchBadr Benjelloun
Dec 31, 2021·Systems Biology in Reproductive Medicine·Faiza Hanif WaghuSusan Idicula-Thomas

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Methods Mentioned

BETA
genotyping

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