Follicular atresia and infertility in rats treated with a gonadotropin-releasing hormone antagonist

Endocrinology
K L SharpeM W Vernon

Abstract

Adverse effects of the GnRH antagonist Antide on folliculogenesis and fertility were noted when we were evaluating the therapeutic value of Antide on endometriosis in a rat model. Cyclic rats with (n = 56) and without (n = 18) surgically induced endometriosis received Antide (2 mg/kg) or vehicle at noon on days 0 (proestrus), 3, 6, and 9. Rats were killed at noon on days 0, 6, 12, 18, 24, 30, 42, and 165. The number of antral follicles and the number of atretic antral follicles evaluated did not differ (P greater than 0.05) between endometriosis and control rats. Antide-treated rats had more (P less than 0.05 ) atretic antral follicles (64.7%) than vehicle-treated rats (15.3%). Antide-treated rat ovaries contained fewer corpora lutea than those of vehicle-treated rats on days 6, 12, and 18. No corpora lutea were found in Antide-treated rat ovaries after day 18. The abnormal ovarian morphology of the Antide-treated rats persisted for the duration of the project (165 days). Fertility (rats without endometriosis) was assessed by mating vehicle-and Antide-treated rats at spontaneous proestrus (n = 8) for eight posttreatment cycles as well as after follicular stimulation (n = 2). All vehicle-treated and no Antide-treated rats became...Continue Reading

Citations

Jul 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F QueredaP Acién
May 4, 2005·Fertility and Sterility·Douglas R DanforthChad I Friedman
Nov 5, 2011·Biology of Reproduction·Julie A W Stilley, Kathy L Sharpe-Timms
Mar 1, 1994·American Journal of Reproductive Immunology : AJRI·W B NothnickM W Vernon
Apr 13, 2002·Annals of the New York Academy of Sciences·Kathy L Sharpe-Timms
Apr 19, 2005·Treatments in Endocrinology·Juergen M WeissMichael Ludwig

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