PMID: 3768842Dec 1, 1986Paper

Follicular center cell lymphoma. Morphologic data relating to observer reproducibility

Cancer
I Dardick, D R Caldwell

Abstract

Subjectivity and observer variation in non-Hodgkin's lymphoma continues to plague current classification schemes. It was thought important to assess objectively derived morphometric data to see if three categories of follicular center cell (FCC) lymphomas, follicular small cleaved cell, follicular mixed small cleaved and large cell, and diffuse and nodular large cell, actually fall into distinctly separate classes based on nuclear parameters. Mean nuclear area, contour index and invagination depth of neoplastic lymphocytes, and the percentage of invaginated and clefted nuclear profiles in each example of FCC lymphoma were evaluated by three different approaches. Results obtained from distribution of the morphometric data in scatter diagrams, calculation of the overlap index, and linear regression values, all revealed considerable (but variable) degrees of overlap between the three FCC subtypes regardless of the nuclear parameter employed. Where separation between FCC lymphomas was maximal, although still incomplete, there was no consistent correlation between the nuclear parameter and the pair of FCC lymphomas being compared. At least in terms of nuclear morphological features, non-Hodgkin's lymphomas of FCC type seem to repres...Continue Reading

References

Mar 1, 1983·Journal of Ultrastructure Research·G SetterfieldJ G Kaplan
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Citations

Nov 20, 1998·Hematological Oncology·V Canzonieri, A Carbone
Apr 1, 1988·Journal of Clinical Pathology·M W StevensA E Woods
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A M HanbyW M Gregory
Apr 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H B SchultzP Hougaard
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M BergmannH K Müller-Hermelink
Feb 21, 2006·British Journal of Haematology·Jorg MichelsGraham Packham

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