Follicular dendritic cell tumor of the liver associated with Epstein-Barr virus

Japanese Journal of Clinical Oncology
Li-Yuan BaiPo-Min Chen

Abstract

Follicular dendritic cell tumors are an uncommon neoplasm. About half of all cases occur in the lymph nodes, especially in the neck region. Follicular dendritic cell tumors of the liver are even rarer. In this article we report a case of a hepatic follicular dendritic cell tumor. A 30-year-old female was noted to have a hepatic mass 6 cm in size in segment 6. The patient underwent a right lobectomy of the liver. Microscopically, the lesion was an admixture of spindle cells and inflammatory cells, chiefly lymphocytes, plasma cells, histiocytes and a few neutrophils. The spindle cells were arranged in a wavy pattern, with a vague cellular border and eosinophilic cytoplasm. These tumor cells were immunoreactive to CD21 and CD68. The test for Epstein-Barr virus (EBV)-encoded nuclear RNAs using in situ hybridization was also positive. Although hepatic follicular dendritic cell tumors appear similar to conventional inflammatory pseudotumors in terms of histology, they should be regarded as a clonal proliferation of follicular dendritic cells. In contrast to follicular dendritic cell tumors in extrahepatic areas, hepatic follicular dendritic cell tumors have a strong association with EBV and a greater inflammatory component and are mo...Continue Reading

References

Jul 1, 1986·Journal of Clinical Pathology·P P Anthony, P U Telesinghe
Oct 1, 1995·Human Pathology·D A ArberL M Weiss
Mar 1, 1993·The American Journal of Surgical Pathology·T W ShekK W Chan
Aug 1, 1996·The American Journal of Surgical Pathology·B Perez-OrdonezJ Rosai
Nov 1, 1996·The American Journal of Surgical Pathology·D A Arber, L M Weiss
Oct 10, 1998·American Journal of Hematology·R FonsecaA Tefferi
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R E SchwarzD A Arber
Apr 3, 2001·Journal of Pediatric Surgery·M SakaiY Tsuchida
Apr 13, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·T C ChenK F Ng
Aug 4, 2001·Human Pathology·R N ShahW B Laskin
Nov 22, 2001·The American Journal of Surgical Pathology·D A Arber, L M Weiss
Jan 15, 2004·Pathology International·Hisashi HoriguchiHirotaka Ohse
Mar 19, 2004·Pathology Oncology Research : POR·Ferenc BrittigGábor Kelényi
Aug 13, 2005·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Ken-ichi TogashiManabu Isoda

❮ Previous
Next ❯

Citations

Sep 18, 2012·Diagnostic Pathology·Yang LiuEn-Hua Wang
Jun 13, 2013·Critical Reviews in Oncology/hematology·Caner SayginNukhet Tuzuner
Aug 5, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Paulo N MartinsMarcelo Facciuto
Mar 6, 2015·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Yoshiyuki KitamuraHiroshi Honda
Jan 22, 2013·Human Pathology·Sherif A RezkLawrence M Weiss
Jun 20, 2016·Seminars in Diagnostic Pathology·Fabio Facchetti, Luisa Lorenzi
Mar 2, 2010·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Tae Wook KangHye Jong Song
Jan 14, 2011·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Qiu Long-HuaFeng Xiao-Yuan
May 29, 2014·Korean Journal of Pathology·Shien-Tung PanShih-Sung Chuang
Mar 29, 2014·Head and Neck Pathology·Turki Al-HussainMohammad Anas Dababo
Apr 18, 2017·Molecular and Clinical Oncology·Xudong ZhangXihu Qin
Jun 14, 2013·Oncology Letters·Tengpeng HuMingzhi Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.