Follicular development during the luteal phase of the human menstrual cycle

The Journal of Clinical Endocrinology and Metabolism
K P McNattyE V Van Hall

Abstract

The aims of the present studies were to determine the number, size range, health, and steroidogenic activities of antral follicles in normal human ovaries during the luteal phase of the menstrual cycle. Steroidogenic activity was assessed from the levels of androstenedione, testosterone, and estradiol in follicular fluid and the levels of extant and FSH-stimulable aromatase activity and FSH-stimulable progestin synthesis in the granulosa cells. Data for luteal phase ovaries were compared to those obtained for ovaries from the late follicular phase. On average, 94% (range, 70-100%) of the luteal phase follicles (greater than or equal to 1 mm diameter) were atretic as assessed by oocyte viability and granulosa cell number. The largest healthy follicles during the mid- to late luteal phase were 4-4.5 mm in diameter; these contained high levels of aromatizable androgen (500-2000 ng/ml), low levels of estradiol (less than 10 ng/ml), and granulosa cells with an extant level of aromatase activity 200 times lower than that in a preovulatory follicle. Based on these biochemical criteria, healthy (luteal phase) follicles were not distinguishable from atretic follicles. Granulosa cells from the luteal phase follicles were responsive to FS...Continue Reading

Citations

May 1, 1997·Journal of Assisted Reproduction and Genetics·S Bar-AmiH Gitay-Goren
Feb 21, 2013·Journal of Assisted Reproduction and Genetics·Marina C PeluffoMary B Zelinski
Feb 8, 2013·Journal of Assisted Reproduction and Genetics·Dong Zi YangZuanyu He
Jan 1, 1987·Journal of Steroid Biochemistry·D T Baird
Jan 1, 1987·Journal of Steroid Biochemistry·S G Hillier
Jan 1, 1987·Journal of Steroid Biochemistry·G S DiZeregaG Westhof
Feb 1, 1984·Molecular and Cellular Endocrinology·K M HendersonD A Heath
Feb 1, 1991·Molecular and Cellular Endocrinology·S G HillierA J Mason
Feb 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·H AdlercreutzL E Vickery
Dec 26, 2001·Archives of Medical Research·N S Macklon, B C Fauser
Jun 2, 2006·Reproduction, Fertility, and Development·Kenneth P McNattyJennifer L Juengel
Nov 10, 2011·Human Reproduction Update·Angela R BaerwaldRoger A Pierson
Oct 15, 2009·Molecular Human Reproduction·Stephen G Hillier
May 11, 2010·Journal of Assisted Reproduction and Genetics·Giuliano M BedoschiPaula Andrea Navarro
Aug 31, 2013·Fertility and Sterility·Hakan CakmakMitchell P Rosen
Jan 18, 2006·Reproductive Biomedicine Online·J-N Hugues, I Cédrin Durnerin
May 26, 2012·Theriogenology·G P AdamsA R Baerwald
Oct 30, 2016·Fertility and Sterility·Jean NassarRenato Fanchin
May 16, 2003·Biology of Reproduction·Angela R BaerwaldRoger A Pierson
Apr 1, 2017·Current Opinion in Obstetrics & Gynecology·Alberto VaiarelliFilippo M Ubaldi
Mar 3, 2015·Journal of Korean Medical Science·Jee Hyun KimSeok Hyun Kim
Jan 1, 1988·Annals of the New York Academy of Sciences·D T BairdA S McNeilly
Jan 1, 1988·Annals of the New York Academy of Sciences·A PellicerA H De Cherney
Aug 22, 2001·Biology of Reproduction·A J Zeleznik
Feb 1, 1997·Endocrine Reviews·B C Fauser, A M Van Heusden
Apr 29, 2015·Current Opinion in Obstetrics & Gynecology·Hakan Cakmak, Mitchell P Rosen
Mar 10, 2016·Hormone Molecular Biology and Clinical Investigation·Heather C M AllawayMary Jane De Souza
Sep 3, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A R Baerwald, R A Pierson

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