PMID: 6969966Jan 1, 1981Paper

Follicular development in the neonatal mouse ovary; effect of epidermal growth factor

Acta Endocrinologica
S Lintern-MooreD Robertson

Abstract

The growth of the ovary has been studied in the mouse after administration of epidermal growth factor (EGF). Newborn females injected daily with EGF for the first 5 days of life showed a retardation of ovarian development. The number of follicles in the resting pool (small follicles) was significantly greater than in control animals and there were fewer growing follicles at more advanced stages of development (types 3b and 4). The percentage of mitotic figures in the follicular and surface epithelia of the ovary and the epithelium of the extra-ovarian rete was also significantly reduced after EGF. The results indicate that EGF may inhibit rather than promote the growth of follicles in the neonatal mouse ovary in vivo.

Citations

Apr 1, 1982·Developmental Biology·E D Adamson, J B Warshaw
May 1, 1984·Developmental Biology·E D Adamson, J Meek
Jul 1, 1983·Molecular and Cellular Endocrinology·R St-ArnaudF Labrie
Feb 1, 1986·Molecular and Cellular Endocrinology·J G ChabotG Pelletier
Feb 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J J ChristiansenK Nielsen
Jul 1, 1983·Journal of Steroid Biochemistry·D W SchombergJ S Mondschein
Nov 15, 1985·Biochemical and Biophysical Research Communications·A M Nakhla, J P Tam
Jan 1, 1985·Differentiation; Research in Biological Diversity·S NakagawaT Fuwa
Jun 1, 1990·Asia-Oceania Journal of Obstetrics and Gynaecology·S IshiharaM Mizuno
Oct 1, 1985·Journal of Endocrinological Investigation·J W SiebersM Breckwoldt
Sep 1, 1987·The American Journal of Physiology·O ImadaS Nakagawa
Jun 1, 1983·The Journal of Investigative Dermatology·J R Matias, N Orentreich
Apr 14, 1986·Biochemical and Biophysical Research Communications·K MoriK Hayashi

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