Follicular development induced by recombinant luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in anovulatory women with LH and FSH deficiency: evidence of a threshold effect

Current Medical Research and Opinion
Louis St L O'DeaGeorge Hemsey

Abstract

To assess the requirement for luteinizing hormone (LH) in women deficient in LH and follicle-stimulating hormone (FSH). A prospective, randomized, parallel-group, multicentre study was carried out in tertiary care and academic medical centres. Women with anovulatory amenorrhoea > or = 1 year, serum oestradiol (E(2)) < 60 pg/mL (< 220 pmol/L) and low normal serum gonadotrophins were randomized in cycle A to a fixed daily dose of recombinant human (r-h) FSH (150 IU) and r-hLH 0, 25, 75 or 225 IU. Cycles B and C were not randomized. Follicular development, ovulation and luteinization. In cycle A, follicular development was achieved by 63.6% (7/11), 100% (9/9), 72.7% (8/11) and 66.7% (6/9) of patients who received r-hFSH and r-hLH 0, 25, 75 or 225 IU/day, respectively (p = not significant). Among patients with basal serum LH of < 1.2 IU/L, a dose-response relationship of r-hLH to follicular development was observed (p = 0.039). Fourteen of 34 patients (41.2%) wishing to conceive became pregnant. Among patients with hypogonadotrophic hypogonadism (HH) treated with r-hFSH alone, a transition from LH dependence to independence was observed between basal LH values of > or = 1.2 IU/L and < or = 1.6 IU/L. The r-hLH was well tolerated and...Continue Reading

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Citations

Feb 18, 2010·Biologics : Targets & Therapy·Ahmed Gibreel, Siladitya Bhattacharya
Mar 29, 2014·Journal of Human Reproductive Sciences·Gottumukkala Achyuta Rama RajuAmeet Shashikant Patki
Oct 5, 2014·Reproductive Biology and Endocrinology : RB&E·Diego Ezcurra, Peter Humaidan
May 10, 2011·Reproductive Biomedicine Online·Peng Cheang WongUNKNOWN Asia Pacific Fertility Advisory Group
Jun 15, 2012·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Stella MilsomAlistair Jan Gunn
May 7, 2013·General and Comparative Endocrinology·Qingqing WeiYunliang Jiang
Sep 21, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Klaus Bühler, Olaf Naether
Aug 1, 2016·Reproductive Biomedicine Online·Chin-Der ChenShee-Uan Chen
Dec 8, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Wen HeLiuhong Cai
Jul 13, 2011·Reproductive Medicine and Biology·Bruno Lunenfeld

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