PMID: 9437585Jan 23, 1998Paper

Follicular dominance in cattle is associated with divergent patterns of ovarian gene expression for insulin-like growth factor (IGF)-I, IGF-II, and IGF binding protein-2 in dominant and subordinate follicles

Domestic Animal Endocrinology
W YuanM C Lucy

Abstract

A decrease in insulin-like growth factor (IGF) binding protein (BP) amount occurs within the follicular fluid of dominant ovarian follicles. At the same time, concentrations of follicular fluid IGF-I do not change. The mRNA for IGF-I, IGF-II, IGFBP-2, and IGFBP-3, in dominant and subordinate follicles were measured to determine if changes in IGF or IGFBP gene expression are associated with follicular dominance. Heifers were ovariectomized during a follicular wave, either during early-dominance (emerging dominant follicle, 9 mm diameter) or mid-dominance (established dominant follicle, 14-16 mm diameter). Follicles were classified as either dominant (DF), subordinate (SF), or not-recruited (NRF; small antral follicles). mRNA was localized by in situ hybridization and measured by image analyses. The IGF-I mRNA (granulosa cells) was greatest in DF and increased in DF, SF, and NRF from early- to mid-dominance. Likewise, IGF-II mRNA (theca cells) was greatest in DF compared with SF or NRF. The IGFBP-2 mRNA (granulosa cells), however, was nearly undetectable in DF, whereas adjacent SF expressed abundant IGFBP-2 mRNA. The NRF were not uniform in their IGFBP-2 expression because only 5 of 13 NRF had IGFBP-2 mRNA. The IGFBP-3 mRNA (gran...Continue Reading

References

Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·J M HammondS F Canning
Jan 1, 1994·Hormone Research·E Y Adashi
Jul 1, 1995·Domestic Animal Endocrinology·L J Spicer, S E Echternkamp
Feb 1, 1996·The Journal of Endocrinology·B R LeeuwenbergK P McNatty
Oct 1, 1996·Biology of Reproduction·R L de la SotaW W Thatcher
Dec 1, 1996·Biology of Reproduction·O J GintherK Kot
Jan 1, 1996·Hormone Research·P MongetD Monniaux

❮ Previous
Next ❯

Citations

Mar 25, 2000·Theriogenology·J W TomG P Adams
Aug 14, 2001·Molecular and Cellular Endocrinology·C S Chamberlain, L J Spicer
May 28, 2003·Cancer Letters·Derek LeRoith, Charles T Roberts
Sep 5, 2002·Hearing Research·Guadalupe CamareroIsabel Varela-Nieto
Jul 27, 2002·Domestic Animal Endocrinology·M Mihm, E J Austin
Mar 19, 1999·Domestic Animal Endocrinology·L J Spicer, C S Chamberlain
Oct 20, 1999·Domestic Animal Endocrinology·R J ScaramuzziB K Campbell
Aug 14, 2002·Reproduction in Domestic Animals = Zuchthygiene·M MihmE J Austin
May 3, 2000·BJU International·E LekåsJ E Damber
Feb 2, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·M MihmP J O'Shaughnessy
Mar 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Kirsty A WaltersEvelyn E Telfer
Sep 19, 2002·The Journal of Veterinary Medical Science·Victor Chisha ZuluYutaka Sawamukai
Aug 22, 2001·Biology of Reproduction·O J GintherK Kot
Aug 22, 2001·Biology of Reproduction·J E FortuneA M Turzillo
Oct 27, 2004·Molecular and Cellular Endocrinology·L J SpicerD T Allen
Mar 8, 2012·Reproduction, Fertility, and Development·Matthew C Lucy
Aug 24, 1999·Endocrine Reviews·L PoretskyL C Giudice
Apr 22, 2016·The Journal of Reproduction and Development·Takashi Shimizu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.