Follicular fluid high density lipoprotein-associated micronutrient levels are associated with embryo fragmentation during IVF.

Journal of Assisted Reproduction and Genetics
Richard W BrowneVictor Y Fujimoto

Abstract

To investigate whether follicular fluid lipid-soluble micronutrients are associated with embryo morphology parameters during IVF. Follicle fluid and oocytes were obtained prospectively from 81 women. Embryo morphology parameters were used as surrogate markers of oocyte health. HDL lipids and lipid-soluble micronutrients were analyzed by high-pressure liquid chromatography. Non-parametric bi-variate analysis and multivariable ordinal logistic regression models were employed to examine associations between biochemical and embryo morphology parameters. Follicular fluid HDL cholesterol (r = -0.47, p < 0.01), alpha-tocopherol (r = -0.41, p < 0.01), delta-tocopherol (r = -0.38, p < 0.05) and beta-cryptoxanthine (r = -0.42, p < 0.01) are negatively correlated with embryo fragmentation. Ordinal logistic regression models indicate that a 0.1 mumol/L increase in beta-cryptoxanthine, adjusted for gamma-tocopherol, is associated with a 75% decrease in the cumulative odds of higher embryo fragmentation (p = 0.010). Follicular fluid HDL micronutrients may play an important role in the development of the human oocyte as evident by embryo fragmentation during IVF.

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Citations

Apr 25, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Kylie R DunningRebecca L Robker
Jan 14, 2016·Journal of Assisted Reproduction and Genetics·Keewan KimRichard W Browne
Nov 12, 2010·Trends in Endocrinology and Metabolism : TEM·Scott M GordonW Sean Davidson
Dec 15, 2010·Fertility and Sterility·Victor Y FujimotoMina Alikani
Jun 17, 2011·Fertility and Sterility·Lindsay M MainsBradley J Van Voorhis
Oct 31, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jeffrey A WelgeLaura A Woollett
Feb 9, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·J A GriegerC T Roberts
May 23, 2014·The Journal of Clinical Endocrinology and Metabolism·Enrique F SchistermanGermaine M Buck Louis
Aug 3, 2018·Development and Psychopathology·Laura M GlynnMolly Fox
Oct 26, 2016·Development and Psychopathology·Trude ReinfjellLars Wichstrøm
Jul 3, 2013·Reproduction, Fertility, and Development·Benner G AlvesMaria L Gambarini
Oct 12, 2019·Free Radical Biology & Medicine·Irantzu Pérez-RuizJosé-Ignacio Ruiz-Sanz
Jan 6, 2021·Fertility Research and Practice·Roshan NikbakhtMahin Taheri Moghadam

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