Follicular fluid levels of interleukin-10 and interferon-gamma do not predict outcome of assisted reproductive technologies

American Journal of Reproductive Immunology : AJRI
Zivile CerkieneAudrone Usoniene

Abstract

Follicular fluid (FF) and surrounding tissue contains various lymphocytes that synthesize different cytokines. The other sources of cytokines are ovarian somatic cells. FF provides microenvironment for the oocyte and contains immunological factors for the regulation of its development. Changes in expression and concentrations of certain cytokines can influence oocyte and embryo quality, resulting in a reduced ability to implant. Some data shows that follicular environment depends on infertility indication. The purpose of our study was to investigate whether cytokines interleukin-10 (IL-10) and interferon-gamma (IFN-gamma) are released in the human FF and also to evaluate impact of those cytokines on fertilization rate, cleavage rate, embryo quality, and pregnancy rate. Couples treated by assisted reproductive technologies were selected for this study. A total of 121 patients participated in the study. Until cytokine detection samples of FF were stored at -20 degrees C. In vitro fertilization or intracytoplasmic sperm injection procedure was used depending on the indication. After 72 hr, on the day of transfer, embryo morphology was evaluated. Embryo transfer based on embryo morphology was performed. Commercial enzyme-linked imm...Continue Reading

References

Jan 1, 1994·Critical Reviews in Immunology·S A RobertsonT G Wegmann
Sep 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·G GrassoM Muscettola
Oct 1, 1995·Journal of Assisted Reproduction and Genetics·M H OzörnekU Kuhn
Sep 1, 1996·American Journal of Reproductive Immunology : AJRI·M D SrivastavaB I Srivastava
Feb 1, 1997·American Journal of Reproductive Immunology : AJRI·E GevaA Amit
Mar 26, 1998·Journal of Assisted Reproduction and Genetics·H BiliS Mantalenakis
Jan 14, 1999·Human Reproduction·F C DenisonS C Riley
Nov 1, 2000·Fertility and Sterility·M R GazvaniC Kingsland
Mar 29, 2001·American Journal of Reproductive Immunology : AJRI·M E HammadehW Schmidt
Nov 5, 2002·Fertility and Sterility·Andres SalumetsTimo Tuuri
Dec 10, 2002·Reproductive Biomedicine Online·T HardarsonR G Edwards
Mar 17, 2004·Reproduction, Fertility, and Development·Snjezana Zidovec LepejRenata Mazuran
Nov 6, 2004·Journal of Assisted Reproduction and Genetics·Annika StrandellAnn Wallin

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Citations

May 6, 2009·Reproductive Biology and Endocrinology : RB&E·Alberto RevelliPaolo Rinaudo
Nov 26, 2013·Molecular Reproduction and Development·Sarah L FieldNicolas M Orsi
Jul 8, 2014·Immunological Investigations·Taghrid M GaafarAmira M Osman
Jan 1, 2013·International Journal of Reproductive Medicine·C McRaeJ Fisher

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