Follicular fluid levels of the long pentraxin PTX3

Journal of the Society for Gynecologic Investigation
Alessio PaffoniC Garlanda

Abstract

Pentraxin-3 (PTX3) is a long pentraxin that plays a key role in female fertility as a structural and essential constituent of the cumulus oophorus extracellular matrix. Despite considerable evidence supporting this role of PTX3 in mice, data in humans are scanty. The aim of the present study was (1) to evaluate follicular fluid concentrations of PTX3; (2) to test the hypothesis that levels of the molecule correlate with oocyte characteristics (corona radiata, aspect of the cumulus, nuclear maturity, and fertilization); and (3) to evaluate the possibility that peripheral concentration of PTX3 may be of clinical help in monitoring ovarian hyperstimulation. ELISA was used to determine PTX3 concentration. Levels of PTX3 were tested in 96 follicles. The mean +/- SD and the median (interquartile range) were 17.9 +/- 18.3 and 12.1 (6.5-23.6) ng/mL, respectively. Levels of the molecule did not appear to be normally distributed. At the day of ovum pick-up, levels of PTX3 were 6.3-fold higher in follicular fluid than in peripheral blood (95% CI, 3.6-9.0). No statistically significant difference emerged linking follicular fluid concentration of PTX3 and oocyte quality. In a series of ten women, plasma concentration of PTX3 did not vary du...Continue Reading

References

Mar 1, 1986·Journal of Reproduction and Fertility·A A TempletonD T Baird
Apr 15, 2003·Journal of Cell Science·Caroline M Milner, Anthony J Day
Mar 18, 2005·Annual Review of Immunology·Cecilia GarlandaAlberto Mantovani

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Citations

Sep 11, 2007·Journal of Clinical Immunology·Alberto MantovaniBarbara Bottazzi
Oct 30, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Fabiana CilloFulvio Gandolfi
May 29, 2012·Fertility and Sterility·Hiroharu KobayashiShinya Toyokuni
Nov 11, 2009·Journal of Reproductive Immunology·Cecilia GarlandaFederica Moalli
Aug 5, 2008·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Guido RagniEdgardo Somigliana
Jan 9, 2008·International Journal of Andrology·Andrea DoniCecilia Garlanda
Oct 13, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Annika SonessonJohan Malm
Feb 16, 2006·Journal of Leukocyte Biology·Barbara BottazziAlberto Mantovani

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