PMID: 6403395Feb 1, 1983Paper

Follicular fluid stimulation of estrogen secretion by immature porcine granulosa cells

Molecular and Cellular Endocrinology
F Ledwitz-Rigby

Abstract

Fluid from large (6-12 mm) porcine follicles (LFFl) enhanced estrogen secretion by granulosa cells from small (1-2 mm) antral porcine follicles during 3-day incubations. Shorter incubations with LFFl or of any length with fluid from small follicles were inconsistent in elevating estrogen secretion. Estrogen was undetectable in freshly collected cells. Addition of 0.14-0.7 micrograms/ml androgens increased estrogen secretion but addition of androgen in a concentration equivalent to that in charcoal-treated LFFl (140 pg/ml) did not. FSH stimulated progesterone but not estrogen secretion. Pretreatment with FSH did not enhance LFFl stimulation of aromatase activity, nor did pretreatment with LFFl influence FSH action on aromatase. These observations suggest the presence of an aromatase stimulator in fluid from nonatretic follicles. By stimulating estrogen production the factor might contribute to follicle development and prevent an increase of the androgen/estrogen ratio which has been proposed to influence atresia.

References

Apr 1, 1979·Molecular and Cellular Endocrinology·F Ledwitz-Rigby, B W Rigby
Aug 1, 1979·Biology of Reproduction·G GiboriJ L Chien
Aug 1, 1975·Endocrinology·J P LouvetG T Ross
Feb 1, 1982·Biology of Reproduction·A E Beer, J O Sio

❮ Previous
Next ❯

Citations

Jan 1, 1987·Journal of Steroid Biochemistry·F Ledwitz-Rigby
Dec 13, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dmitrijus KirilovasTord Naessen
Oct 23, 2016·Reproductive Biology and Endocrinology : RB&E·Deepika Garg, Zaher Merhi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.