Follicular growth and atresia during the last half of the luteal phase of the guinea pig estrous cycle: relation to serum progesterone and estradiol levels and utero-ovarian blood flow

Endocrinology
D R Garris, D Foreman

Abstract

The relationships among follicular growth, changes in serum progesterone (P) and estradiol (E) levels, and utero-ovarian blood flow (OBF) through the guinea pig ovary were examined during days 7-16 of the luteal phase (day 0 = estrus) of the estrous cycle and during the subsequent ovulatory (proestrous-estrous) period. Follicles were classified as either viable or atretic based on strict criteria and grouped according to diameter. No changes in follicular growth were observed between days 7-9 of the cycle when serum P levels were elevated and OBF was at low rates. Between days 13-15 when serum P levels were low and both OBF and serum E levels were rising, there was a dramatic increase in the number of viable follicles present in all follicle classes. As the percentage of viable follicles increased, the number of atretic follicles in each size population decreased. Peaks in the number of large follicles (300-450 microns), OBF, and serum E levels were observed during the subsequent ovulatory period. These data suggest that as luteal activity declines during the last half of the estrous cycle, follicular recruitment and growth are stimulated. The concomitant elevations in OBF suggest a supportive role for this parameter in follicu...Continue Reading

Citations

Aug 19, 2003·Tissue & Cell·David R Garris, Bryan L Garris
Jul 1, 1988·American Journal of Obstetrics and Gynecology·D H BaradA Makris
Dec 8, 2015·Journal of Zhejiang University. Science. B·Jun-rong LiFang-xiong Shi
Oct 13, 2007·Theriogenology·J C SadeuJ Smitz
Aug 21, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Terrence E SweeneySarita Soares
Jan 1, 1993·Endocrine Research·D ForemanD Garris
Jun 24, 2020·International Journal of Molecular Sciences·Jin BaiDong-Bao Chen

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