PMID: 7545296Aug 29, 1995Paper

Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity

Proceedings of the National Academy of Sciences of the United States of America
Joachim L SchultzeL M Nadler

Abstract

In the tumor-bearing host, T cells invariably fail to induce a clinically significant antitumor immune response. Although model systems support the existence of tumor peptide antigens, the molecular interactions critical for antigen presentation by the tumor cell remain unresolved. Here, we demonstrate that human follicular lymphoma cells are highly inefficient at presenting alloantigen despite their strong expression of major histocompatibility complex and low-to-intermediate expression of some adhesion and B7 costimulatory molecules. Activation of follicular lymphoma cells via CD40 induces or up-regulates both adhesion and B7 costimulatory molecules essential to repair this defect. More importantly, once primed, alloreactive T cells efficiently recognize unstimulated follicular lymphoma cells. Thus, correction of defective tumor immunity requires not only expression of major histocompatibility complex but also sufficient expression of multiple adhesion and costimulatory molecules.

References

Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·V A BoussiotisL M Nadler
Oct 1, 1993·Immunology Today·L ChenK E Hellström
Jan 1, 1994·Annual Review of Immunology·J BanchereauS Saeland
Nov 1, 1994·The Journal of Experimental Medicine·V A BoussiotisL M Nadler
Apr 1, 1993·The Journal of Experimental Medicine·E A Ranheim, T J Kipps
Oct 1, 1993·Current Opinion in Immunology·D M Pardoll
Oct 1, 1994·Current Opinion in Immunology·S Ostrand-Rosenberg
Jan 1, 1994·Annual Review of Immunology·T BoonA Van Pel
Jun 2, 1994·Nature·D M Pardoll
Jun 1, 1993·Immunology Today·D M Pardoll

❮ Previous
Next ❯

Citations

Sep 1, 1996·Cancer Metastasis Reviews·P F Searle, L S Young
Jan 15, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Sonia NéronJean-François Leblanc
Sep 19, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alexey Popov, Joachim L Schultze
Sep 28, 2005·Cancer Immunology, Immunotherapy : CII·Koji Tamada, Lieping Chen
May 12, 2005·Cancer Immunology, Immunotherapy : CII·Johannes ScheteligMartin Bornhäuser
Aug 29, 2012·Cancer Immunology, Immunotherapy : CII·Masayasu NaitoGordon J Freeman
Aug 5, 2004·Current Oncology Reports·Renier J Brentjens
Sep 18, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Javier Briones
Jul 17, 1998·The American Journal of Pathology·D M DorfmanG J Freeman
Oct 26, 1999·Immunology Today·R T CostelloD Olive
Jun 1, 1996·Blood Reviews·J SchultzeJ G Gribben
Jan 21, 2000·Experimental Hematology·N RenardG Salles
Jun 26, 1999·Biochimica Et Biophysica Acta·J G Gribben
Feb 22, 2002·Critical Reviews in Oncology/hematology·Nicolas MounierChristian Gisselbrecht
Sep 10, 2003·Seminars in Cancer Biology·Hendrik Veelken
Jun 29, 2007·Nature Clinical Practice. Oncology·Ben SprangersAn D Billiau
Jul 27, 2001·Clinical and Experimental Immunology·A J LeeR F James
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·K T HallG J Freeman
Sep 1, 1996·The Journal of Experimental Medicine·Y GuoY Liu
May 14, 2003·The Journal of Experimental Medicine·Makoto MurataStanley R Riddell
Jul 2, 2005·Cancer Biotherapy & Radiopharmaceuticals·Siguo HaoJim Xiang
Sep 30, 2006·Human Gene Therapy·Peter M RabinovichSherman M Weissman
Nov 26, 2008·Human Gene Therapy·Peter M RabinovichErkut Bahceci
Apr 3, 2003·Journal of the National Cancer Institute·Javier BrionesRonald Levy
May 13, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wandi ZhangCatherine J Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.