Follicular sterol composition in gonadotrophin stimulated women with polycystic ovarian syndrome

Molecular and Cellular Endocrinology
E Vrtacnik BokalD Rozman

Abstract

This is the first study evaluating whether oocyte development and fertilization competence are related to intrafollicular concentration of cholesterol, meiosis-activating sterols and progesterone, after human chorionic gonadotrophin (HCG) administration of women with polycystic ovarian syndrome (PCOS). The concentration of follicular fluid meiosis-activating sterol (FF-MAS) significantly increased in the periovulatory period from 10-14 to 34-38 h after HCG administration, while the concentration of testis meiosis-activating sterol (T-MAS) decreased, suggesting a HCG-dependent inhibition of sterol Delta14-reductase. There was no correlation between follicular lanosterol, FF-MAS, T-MAS, and progesterone concentrations and the presence or absence of MII oocytes. Interestingly, free cholesterol level was significantly lower and FF-MAS/cholesterol and progesterone/cholesterol ratios significantly higher in follicles containing MII oocytes compared to follicles from which oocytes were not retrieved. Yet, fertilization and embryo quality did not correlate with follicular sterols. This knowledge should be beneficial for the implementation of protocols for in vitro maturation process, usually used in PCOS patients.

References

Jan 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J ItskovitzJ E Sealey
Jan 1, 1988·Annals of the New York Academy of Sciences·L L Veeck
Oct 1, 1995·British Journal of Obstetrics and Gynaecology·P R BrinsdenH S Jacobs
May 1, 1995·Molecular Reproduction and Development·P Blondin, M A Sirard
Apr 1, 1996·Journal of Assisted Reproduction and Genetics·T Tomazevic, H Meden-Vrtovec
Jan 7, 1998·Fertility and Sterility·M A AboulgharY M Amin
Jun 10, 1998·Human Reproduction·E Vrtacnik-Bokal, H Meden-Vrtovec
Dec 10, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·A G ByskovC Y Andersen
Dec 8, 2000·Steroids·N Chabbert-BuffetaP Bouchard
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B LindenthalJ K Kelleher
Mar 27, 2001·Human Reproduction·C GrøndahlP Hyttel
Nov 13, 2001·Fertility and Sterility·G F Erickson, S Shimasaki
May 4, 2002·Molecular and Cellular Endocrinology·D RozmanR Frangez
May 4, 2002·Molecular and Cellular Endocrinology·Anne Grete ByskovLise Leonardsen
May 4, 2002·Molecular and Cellular Endocrinology·Alex TsafririMalka Popliker
Aug 19, 2003·Human Reproduction·S CukurcamU Eichenlaub-Ritter
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group

❮ Previous
Next ❯

Citations

Aug 16, 2011·Zygote : the Biology of Gametes and Early Embryos·F Marco-JiménezM P Viudes-de-Castro
May 29, 2009·Animal Reproduction Science·Francisco Marco-JiménezJosé-Salvador Vicente
Mar 26, 2010·NMR in Biomedicine·Eva Piñero-SagredoVicent Esteve
Mar 9, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Klementina Fon TacerDamjana Rozman
Jun 15, 2007·Physiological Genomics·Klementina Fon TacerDamjana Rozman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.