PMID: 8943776Oct 1, 1996Paper

Follistatin concentrations in male sheep increase following sham castration/castration or injection of interleukin-1 beta

The Journal of Endocrinology
D J PhillipsD M de Kretser

Abstract

Plasma follistatin (FS) concentrations were determined after castration (n = 5) or sham castration (n = 4) of mature rams. Both treatments resulted in a prolonged increase in FS between 7 and 19 h after surgery, which returned to pretreatment concentrations by 24 h. Tumour necrosis factor-alpha (TNF-alpha), a sensitive maker of an acute-phase response, was undetectable in plasma, indicating that the FS response was not induced by trauma due to surgery. In a second experiment, injection of castrated rams (n = 4) with ovine recombinant interleukin-1 beta, an acute-phase mediator, resulted in a sustained rise in FS concentrations within 4 h of injection. Plasma TNF-alpha concentrations increased transiently within 1 h of interleukin-1 beta injection, indicating that an acute-phase response had been initiated. Plasma follicle-stimulating hormone (FSH) concentrations were significantly decreased at 8 and 24 h after interleukin-1 beta injection, strongly suggestive of an inhibitory effect of increased FS concentrations on the secretion of FSH. Injection of castrated rams (n = 2) with a control preparation of recombinant interleukin-2 did not induce an acute-phase response, and plasma FS and FSH concentrations were unaffected. These d...Continue Reading

Citations

Feb 7, 2013·Seminars in Immunopathology·Paschalis SiderasEvangelos Andreakos
Oct 24, 1998·Journal of Reproductive Immunology·D M de Kretser, D J Phillips
Jul 14, 2001·Molecular and Cellular Endocrinology·D M de KretserN G Wreford
Jul 14, 2001·Molecular and Cellular Endocrinology·G JenkinE Wallace
Jul 14, 2001·Molecular and Cellular Endocrinology·D J PhillipsD M de Kretser
Apr 30, 1999·Molecular and Cellular Endocrinology·C E RussellD J Phillips
Jan 7, 2016·The Journal of Endocrinology·Anne R O'ConnellJennifer L Juengel
Mar 6, 2009·Cytokine & Growth Factor Reviews·David J PhillipsMark P Hedger
Dec 29, 2004·Domestic Animal Endocrinology·David J Phillips
Nov 1, 2011·Molecular and Cellular Endocrinology·David M de KretserMark P Hedger
Jun 26, 1998·Clinical Endocrinology·U MichelR Nau
Sep 6, 2005·Veterinary Immunology and Immunopathology·David J PhillipsDavid M de Kretser
Nov 27, 2008·Reproduction in Domestic Animals = Zuchthygiene·Y XiaJ R McFarlane
Aug 3, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hui WuMark P Hedger
Sep 27, 2002·Experimental Biology and Medicine·Corrine WeltAlan Schneyer
Nov 13, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Laura F NewellShernan G Holtan
Nov 4, 1998·Frontiers in Neuroendocrinology·D J Phillips, D M de Kretser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.