PMID: 11904608Mar 21, 2002Paper

Follistatin-free activin A is not associated with preterm birth

American Journal of Obstetrics and Gynecology
Eileen Y WangNational Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network

Abstract

The purpose of this study was to determine whether follistatin-free activin A (an inhibin-related protein with rising serum levels before term labor) is associated with spontaneous preterm birth in an outpatient population. From 10 centers, 2929 women were enrolled in the Preterm Prediction Study. Plasma was isolated from blood samples obtained at 24 and 28 weeks of gestation and stored. A nested case-controlled study was performed; there were 197 women with spontaneous preterm birth before 37 weeks of gestation with 24-week samples and 142 cases with 28-week samples that were matched to an equal number of term control samples from each time point. A follistatin-free activin A enzyme-linked immunosorbent assay was performed, with results interpreted as positive or negative (defined as a value less than the assay limit of sensitivity). A comparison of follistatin-free activin A with other tests that were associated with spontaneous preterm birth (alpha-fetoprotein, alkaline phosphatase, cortisol, granulocyte colony-stimulating factor, fetal fibronectin, and cervical interleukin-6) was also performed. The odds ratio for associated spontaneous preterm birth at <37 weeks of gestation if the follistatin-free activin A result was pos...Continue Reading

References

Sep 1, 1991·American Journal of Obstetrics and Gynecology·F PetragliaH Meunier
Dec 1, 1990·Endocrinology·T K WoodruffJ P Mather
Aug 1, 1993·The Journal of Clinical Endocrinology and Metabolism·F PetragliaW Vale
Sep 27, 1993·Journal of Immunological Methods·W L WongJ A Lofgren
Sep 1, 1996·European Journal of Endocrinology·A GallinelliF Petraglia
Jul 31, 1998·The New England Journal of Medicine·R L Goldenberg, D J Rouse
May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews

❮ Previous
Next ❯

Citations

Oct 30, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·K RaeJ McFarlane
Mar 16, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·A Conde-AgudeloJ Villar
Sep 29, 2004·Molecular and Cellular Endocrinology·Shanthi MuttukrishnaIan Sargent
Feb 13, 2003·Clinical Endocrinology·Stephen TongHenry G Burger
Feb 4, 2010·Archives of Gynecology and Obstetrics·Remah Moustafa Kamel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.