Follistatin restricts bone morphogenetic protein (BMP)-2 action on the differentiation of osteoblasts in fetal rat mandibular cells

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Yukiko AbeKatsumasa Maeda

Abstract

We tested whether FS secretion might modulate BMP-2 actions by measuring FS levels and counting bone numbers of rat mandibular cells. In the presence of Dex, BMP-2 stimulated FS secretion at the early phase and augmented bone nodule by neutralizing with FS antibody. We concluded that BMP-2 facilitates FS secretion, and the FS restricts BMP-2 action on osteoblastogenesis. Bone morphogenetic proteins (BMPs) promote the differentiation of osteoprogenitor cells into osteoblasts. Activin A is involved in the regulation of bone formation. Follistatin (FS) antagonizes the bioactivities of BMP and activin A extracellularly. In this study, we tested whether the induction of FS secretion might modulate the effects of BMP-2 on osteoblast development, using the bone nodule-forming cultures of fetal rat mandibular cells. In the presence of dexamethasone (Dex), BMP-2 stimulated the secretion of FS at the early phase (days 3-9) of the culture. Dex alone had no effect, and BMP-2 alone was less effective than the combination of the two. BMP-4 and -6 had little effect on FS secretion. Activin A inhibited the early upregulation of FS secretion when added with BMP-2 and Dex. In the presence of Dex, BMP-2 increased bone nodule numbers when added to...Continue Reading

References

Nov 1, 1994·Calcified Tissue International·S InoueM Muramatsu
Jan 15, 1996·Molecular and Cellular Endocrinology·J P de WinterA J van den Eijnden-van Raaij
Apr 1, 1997·Mechanisms of Development·A FainsodM Blum
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·S IemuraN Ueno
Jul 25, 2000·Journal of Cellular Biochemistry·A E Kearns, M B Demay
Jul 14, 2001·Molecular and Cellular Endocrinology·R Sakai, Y Eto

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Citations

Feb 5, 2014·Clinical & Experimental Metastasis·Hassan Fazilaty, Parvin Mehdipour
Oct 10, 2006·Breast Cancer Research and Treatment·A BellahcèneV Castronovo
Sep 29, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Eric R James
Mar 13, 2012·Molecular and Cellular Endocrinology·B BarakatK L Loveland
Oct 6, 2009·Metabolism: Clinical and Experimental·Pan MaHongchen Liu
Aug 26, 2006·Biochimica Et Biophysica Acta·In Sook KimSoon Jung Hwang
Apr 29, 2006·Developmental Biology·Akito MaeshimaSanjay K Nigam
Feb 17, 2017·The Journal of Pathology·Aurélie BellangerPascale A Cohen
Nov 16, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Geralyn Lambert-MesserlianAlan L Schneyer
Mar 1, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Holly A LeddyWolfgang Liedtke
Sep 17, 2020·Journal of Developmental Biology·Daniel HalloranAnja Nohe
Mar 19, 2019·Frontiers in Bioengineering and Biotechnology·Shorouk Fahmy-GarciaMarjolein van Driel
Apr 19, 2005·The Journal of Biological Chemistry·Ivo KalajzicDavid W Rowe
Apr 20, 2018·International Journal of Molecular Sciences·Annika NordstrandPernilla Wikström

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