Follow Me! A Tale of Avian Heart Development with Comparisons to Mammal Heart Development

Journal of Cardiovascular Development and Disease
Rusty Lansford, Sandra Rugonyi

Abstract

Avian embryos have been used for centuries to study development due to the ease of access. Because the embryos are sheltered inside the eggshell, a small window in the shell is ideal for visualizing the embryos and performing different interventions. The window can then be covered, and the embryo returned to the incubator for the desired amount of time, and observed during further development. Up to about 4 days of chicken development (out of 21 days of incubation), when the egg is opened the embryo is on top of the yolk, and its heart is on top of its body. This allows easy imaging of heart formation and heart development using non-invasive techniques, including regular optical microscopy. After day 4, the embryo starts sinking into the yolk, but still imaging technologies, such as ultrasound, can tomographically image the embryo and its heart in vivo. Importantly, because like the human heart the avian heart develops into a four-chambered heart with valves, heart malformations and pathologies that human babies suffer can be replicated in avian embryos, allowing a unique developmental window into human congenital heart disease. Here, we review avian heart formation and provide comparisons to the mammalian heart.

References

Jan 1, 1979·The Japanese Journal of Physiology·A HirotaK Kamino
Jan 1, 1977·The American Journal of Anatomy·R R MarkwaldF J Manasek
Jul 1, 1992·Respiration Physiology·O Mathieu-CostelloP W Hochachka
Jan 1, 1973·Poultry Science·G P Nirmalan, G A Robinson
Sep 8, 1965·Annals of the New York Academy of Sciences·R L DeHaan
Mar 15, 1968·Experientia·L J Edwards, L S Hnilica
Mar 1, 1968·The Anatomical Record·G H PaffT C Harrell
Jan 15, 1964·Experientia·L S Hnilica
Feb 1, 1967·The American Journal of Physiology·L H Van Mierop
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D Röhme
Aug 1, 1995·Circulation Research·M L Kirby, K L Waldo
Oct 1, 1993·Developmental Biology·V Garcia-Martinez, G C Schoenwolf
Jul 1, 1997·The Anatomical Record·D SedmeraE B Clark
Aug 1, 1997·The American Journal of Physiology·F LiA M Gerdes
Jan 26, 1999·Annals of the New York Academy of Sciences·A D MarmorsteinE Rodriguez-Boulan
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K Tobita, B B Keller
Nov 1, 2001·Annual Review of Cell and Developmental Biology·M Mercola, M Levin
Dec 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·F R SchubertS Dietrich
Jan 11, 2002·Journal of Biomechanical Engineering·L A Taber, J D Humphrey

❮ Previous
Next ❯

Citations

Dec 1, 2020·Frontiers in Cell and Developmental Biology·Jianhong XiaTiejun Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
genetic modifications
delamination
imaging techniques
gene knockout
light sheet microscopy

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Cold Spring Harbor Perspectives in Biology
Johannes G Wittig, Andrea E Münsterberg
Progress in Molecular Biology and Translational Science
Bill ChaudhryDeborah J Henderson
© 2021 Meta ULC. All rights reserved