Follow that botanical: Challenges and recommendations for assessing absorption, distribution, metabolism and excretion of botanical dietary supplements

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Suramya WaidyanathaCynthia V Rider

Abstract

Botanical dietary supplements are complex mixtures containing one or more botanical ingredient(s), each containing numerous constituents potentially responsible for its purported biological activity. Absorption, distribution, metabolism, and excretion (ADME) data are critical to understand the safety of botanical dietary supplements, including their potential for pharmacokinetic botanical-drug or botanical-botanical interactions. However, ADME data for botanical dietary supplements are rarely available and frequently inadequate to characterize their fate in vivo. Based on an assessment of the current status of botanical dietary supplements ADME research, the following key areas are identified that require robust data for human safety assessment: 1) phytochemical characterization including contaminant analysis and botanical authentication; 2) in vitro and/or in vivo data for identifying potential botanical-botanical or botanical-drug interactions and active/marker constituents; 3) robust ADME study design to include systemic exposure data on active/marker constituents using traditional or novel analytical chemistry and statistical approaches such as poly-pharmacokinetics; and 4) investigation of human relevance. A case study wit...Continue Reading

Citations

Oct 1, 2019·Environmental and Molecular Mutagenesis·Derek T BernackiStephanie L Smith-Roe
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Barbara C SorkinGuido F Pauli
Apr 8, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kelly A ShipkowskiCynthia V Rider
May 21, 2021·Journal of Pharmaceutical Analysis·Dingyi YuXiaohui Fan

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