Follow-up nerve conduction studies in CIDP after treatment with IGIV-C: Comparison of patients with and without subsequent relapse

Muscle & Nerve
Russell L ChinNorman Latov

Abstract

Electrodiagnostic studies (EDX) are not performed routinely before treatment suspension in CIDP, and no data exist regarding their value in predicting clinical relapse. Serial EDX (baseline and after IGIV-C therapy) were analyzed from subjects in the ICE clinical trial who responded to IGIV-C treatment and were subsequently re-randomized to placebo in an extension phase. Comparisons were made between subjects who relapsed and those who did not. A total of 55% (6/11) of the Relapse group had an increase in total number of demyelinating findings (DF) versus 8% (1/13) in the No Relapse group (P = 0.023). In the Relapse group, 100% had ≥1 new DF and 73% (8/11) had ≥4 new DF versus 60% (8/13) and 8% (1/13), respectively, in the No Relapse group. An increased total number of DF or the occurrence of ≥4 new DF may indicate a higher risk of clinical relapse after treatment cessation in IGIV-C-responsive patients. Muscle Nerve 52: 498-502, 2015.

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Jul 29, 2010·Muscle & Nerve·Vera BrilUNKNOWN ICE Study Group
Jul 2, 2014·Nature Reviews. Neurology·Norman Latov

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Citations

Jul 9, 2016·Journal of Diabetes and Its Complications·Vera BrilJames W Russell
Feb 13, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Florian HärtigAlexander Grimm
Oct 12, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Vera BrilOrell Mielke
Feb 15, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ali Al-ZuhairyChristian Krarup
Jan 12, 2021·Neurophysiologie clinique = Clinical neurophysiology·Ali Asghar OkhovatFarzad Fatehi
Jul 23, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Monica AlcantaraVera Bril

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