PMID: 8580617Nov 1, 1995Paper

Follow-up of antibodies to growth hormone in 210 growth hormone-deficient children treated with different commercial preparations

Acta Paediatrica
P PirazzoliM Capelli

Abstract

The aim of the study was to evaluate the immunogenicity of different commercial recombinant-growth hormone preparations. The presence of antibodies to growth hormone was tested in 210 growth hormone-deficient children at 6-month intervals during treatment for 6-66 months. The patients were treated with three preparations (groups A, B and C of 70 cases each) having the authentic growth hormone sequence. Groups A and B received hormone synthesized by the recombinant DNA technique in E. coli, while the group C preparation was produced in a mammalian cell line. The preparations showed poor immunogenicity and antibodies were found as follows: 1.4% in patients of group A (1 case: binding capacity 0.2 mg/l and Ka 3.5 10(7) l M-1), 2.8% in patients of group B (2 cases; case 1 binding capacity 0.7 mg/l and Ka 1.5 10(7) l M-1; case 2 binding capacity 0.04 mg/l and Ka of 1.8 10(8) and 6.5 10(6) l M-1), and 8.5% in group C (6 cases; binding capacity from 0.4 to less than 0.02 mg/l, Ka from 1.6 10(7) to 3.8 10(8) l M-1). Only two patients of group C presented the antibodies in two subsequent examinations; in the other patients the positivity was found once. In all patients positive samples were found at intervals of 6-24 months after the st...Continue Reading

References

Jan 1, 1978·The Journal of Clinical Endocrinology and Metabolism·W V Moore
Aug 1, 1987·Archives of Disease in Childhood·R D MilnerP H Rayner
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Oct 1, 1980·The Journal of Clinical Endocrinology and Metabolism·W V Moore, P Leppert
Jun 1, 1964·The Journal of Clinical Investigation·J ROTHS A BERSON
Oct 1, 1964·The Journal of Clinical Endocrinology and Metabolism·M L PARKERW H DAUGHADAY

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Citations

Mar 1, 1997·Indian Journal of Pediatrics·J Krishna
May 19, 2001·Urology·B L HintzA R Kagan
Sep 6, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Toshiaki TanakaPierre C Sizonenko
Feb 10, 2006·Current Medical Research and Opinion·Mike NamakaMaria Melanson
Oct 6, 2010·Farmacia hospitalaria : órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria·B Dorantes Calderón, I M Montes Escalante
Oct 8, 2016·Immunology and Cell Biology·Yann GallaisIsabelle Turbica
Jan 28, 2006·Hormone Research·Judith L Ross
Sep 22, 2009·The Analyst·Asta Kausaite-MinkstimieneArunas Ramanavicius

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