Follow-up of infants with congenital cytomegalovirus and normal fetal imaging

Archives of Disease in Childhood. Fetal and Neonatal Edition
Jacob AmirJoseph Pardo

Abstract

To evaluate the outcome of infants with congenital cytomegalovirus (CMV) infection and normal fetal imaging. Retrospective cohort study. Tertiary paediatric medical centre. 98 infants born to mothers with primary CMV infection in the first and second trimesters (diagnosed by positive amniotic fluid findings) and normal fetal imaging. Initial evaluation included confirmatory urine culture, complete blood count, liver and kidney function tests, funduscopy, brain ultrasound and hearing test. Follow-up included periodic neurological and developmental evaluation, hearing tests until age 5 and Bayley-III Developmental Scale (in some patients). The presence and rate of sequelae of congenital CMV. 52 (53.1%) infants received early antiviral treatment for central nervous system symptoms or signs, mainly lenticulostriatal vasculopathy on postnatal ultrasonography (88.5%). Sensorineural hearing loss was found on first examination in 16 infants (25 ears), of whom 10 also had cranial ultrasound findings; another five with late-onset hearing loss were also treated. The median follow-up time was 32 (12-83) months. Most infants with moderate and severe hearing loss were infected in the first trimester (10 vs 2, p=0.053). At the last assessment...Continue Reading

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Citations

Apr 27, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yechiel Schlesinger
Aug 2, 2017·The Pediatric Infectious Disease Journal·Einat ShmueliEfraim Bilavsky
Aug 22, 2017·Clinical Pediatrics·Jessica L Coleman, Russell W Steele
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Oct 9, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D BucaF D'Antonio
Mar 27, 2021·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Yulia ShlonskyOrit Golan-Shany
May 1, 2021·Ear and Hearing·Bénédicte VosElizabeth M Fitzpatrick

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