Follow-up of pituitary tumor volume in patients with acromegaly treated with pegvisomant in clinical trials

European Journal of Endocrinology
Camilo JimenezRobert F Gagel

Abstract

We examined pituitary tumor volumes in patients treated with pegvisomant for 18 months or longer, and in whom the tumors were monitored for at least 3 years. We present details on 9 of 304 patients in clinical trials with pegvisomant who experienced tumor growth within the first year of treatment. Magnetic resonance images prior to start of pegvisomant and at last follow-up were examined in 43 patients (14% of participating patients). Twenty-nine had received prior radiation therapy (18% of irradiated patients) and all but five received somatostatin analogs between periods of pegvisomant treatment. At follow-up, the median tumor volume was 0.6 cc (range 0.0-19.7 cc), in comparison with 1.6 cc (0.0-19.7 cc) at baseline (P<0.001). Twenty-five patients, of which 23 received radiation therapy, had tumor volume reduction. Seventeen patients had no significant change. One patient, who had not received radiation therapy, had an increase in tumor volume from 1.61 to 1.93 cc. Of the nine patients with tumor growth, six had progressive growth before initiating pegvisomant. Two patients with stable tumors while on octreotide experienced enlargement after octreotide discontinuation but remained stable on long-term pegvisomant therapy. The ...Continue Reading

Citations

Mar 8, 2012·Pituitary·I BernabeuM Marazuela
Dec 15, 2012·PloS One·Jan EggerRon Kikinis
Oct 5, 2010·Neurosurgical Focus·Maria FleseriuDavid M Cook
Mar 30, 2010·Journal of Endocrinological Investigation·A Colao, G Lombardi
Aug 18, 2009·European Journal of Endocrinology·Peter J Trainer
Aug 18, 2009·European Journal of Endocrinology·Thierry BrueUNKNOWN ACROSTUDY investigators
Aug 18, 2009·European Journal of Endocrinology·M BuchfelderUNKNOWN German Pegvisomant Observational Study
Sep 24, 2014·Journal of Endocrinological Investigation·A GiustinaR Pivonello
Jan 30, 2016·Acta neurochirurgica·Benjamin M DaviesKanna K Gnanalingham
May 11, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Fernando CordidoUNKNOWN grupo de Neuroendocrinología de la Sociedad Española de Endocrinología y Nutrición
Jul 24, 2012·Cancer Treatment Reviews·Zuzana TatarXavier Durando
Dec 1, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Philippe ChansonJacques Young
Mar 5, 2013·Scientific Reports·Jan EggerRon Kikinis
Apr 19, 2011·Orvosi hetilap·Erika HubinaMiklós Góth
Sep 24, 2013·Orvosi hetilap·Miklós Góth
May 27, 2014·Pituitary·E Fernandez-RodriguezI Bernabeu
Dec 26, 2012·Computer Methods and Programs in Biomedicine·Jan EggerChristopher Nimsky
Nov 6, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Pamela U FredaA J van der Lely
Jun 9, 2016·Endocrine-related Cancer·Thomas CunyAnne Barlier
Mar 31, 2011·Nature Reviews. Endocrinology·Mark SherlockMichael C Sheppard
Feb 26, 2014·Nature Reviews. Endocrinology·Andrea GiustinaUNKNOWN Acromegaly Consensus Group
Jun 6, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Manish Aghi, Lewis S Blevins
Jun 3, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael MadsenJens O L Jørgensen
Dec 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Jan-Hendrik BuhkMichael Knauth
Dec 10, 2016·European Journal of Endocrinology·Nicholas A TritosBeverly M K Biller
Jul 1, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

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